Lytixar free base

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407386

CAS#: 1166254-80-3 (free base)

Description: Lytixar, also known as LTX-109, is a Synthetic Antimicrobial Peptide, showing activity against Methicillin-Resistant, Vancomycin-Intermediate, Vancomycin-Resistant, Daptomycin-Nonsusceptible, and Linezolid-Nonsusceptible Staphylococcus aureus. LTX-109 demonstrated a MIC range of 2 to 4 μg/ml and dose-dependent rapid bactericidal activity against S. aureus. This activity was not influenced by resistance to other antistaphylococcal agents.

Chemical Structure

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Lytixar free base
CAS# 1166254-80-3 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 407386
Name: Lytixar free base
CAS#: 1166254-80-3 (free base)
Chemical Formula: C43H73Cl4N11O3
Exact Mass: 787.56
Molecular Weight: 933.931
Elemental Analysis: C, 55.30; H, 7.88; Cl, 15.18; N, 16.50; O, 5.14

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 1166254-80-3 (free base)   Lytixar HCl,  

Synonym: Lytixar; LTX-109; LTX 109; LTX109; Lytixar free base; Voxvoganan;

IUPAC/Chemical Name: (S)-2-amino-5-guanidino-N-((S)-1-(((S)-5-guanidino-1-oxo-1-(phenethylamino)pentan-2-yl)amino)-1-oxo-3-(2,5,7-tri-tert-butyl-1H-indol-3-yl)propan-2-yl)pentanamide

InChi Key: ZVOYWSKEBVVLGW-ZDCRTTOTSA-N

InChi Code: InChI=1S/C43H69N11O3/c1-41(2,3)27-23-28-29(35(43(7,8)9)54-34(28)30(24-27)42(4,5)6)25-33(53-36(55)31(44)17-13-20-50-39(45)46)38(57)52-32(18-14-21-51-40(47)48)37(56)49-22-19-26-15-11-10-12-16-26/h10-12,15-16,23-24,31-33,54H,13-14,17-22,25,44H2,1-9H3,(H,49,56)(H,52,57)(H,53,55)(H4,45,46,50)(H4,47,48,51)/t31-,32-,33-/m0/s1

SMILES Code: O=C(N[C@@H](CC1=C(C(C)(C)C)NC2=C1C=C(C(C)(C)C)C=C2C(C)(C)C)C(N[C@@H](CCCNC(N)=N)C(NCCC3=CC=CC=C3)=O)=O)[C@@H](N)CCCNC(N)=N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 933.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Nilsson AC, Janson H, Wold H, Fugelli A, Andersson K, Håkangård C, Olsson P, Olsen WM. LTX-109 is a novel agent for nasal decolonization of methicillin-resistant and -sensitive Staphylococcus aureus. Antimicrob Agents Chemother. 2015 Jan;59(1):145-51. doi: 10.1128/AAC.03513-14. PubMed PMID: 25331699; PubMed Central PMCID: PMC4291342.

2: Saravolatz LD, Pawlak J, Johnson L, Bonilla H, Saravolatz LD 2nd, Fakih MG, Fugelli A, Olsen WM. In vitro activities of LTX-109, a synthetic antimicrobial peptide, against methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, daptomycin-nonsusceptible, and linezolid-nonsusceptible Staphylococcus aureus. Antimicrob Agents Chemother. 2012 Aug;56(8):4478-82. doi: 10.1128/AAC.00194-12. PubMed PMID: 22585222; PubMed Central PMCID: PMC3421571.

3: Isaksson J, Brandsdal BO, Engqvist M, Flaten GE, Svendsen JS, Stensen W. A synthetic antimicrobial peptidomimetic (LTX 109): stereochemical impact on membrane disruption. J Med Chem. 2011 Aug 25;54(16):5786-95. doi: 10.1021/jm200450h. PubMed PMID: 21732630.

4: Scott RW, Tew GN. Mimics of Host Defense Proteins; Strategies for Translation to Therapeutic Applications. Curr Top Med Chem. 2017;17(5):576-589. Review. PubMed PMID: 27411325.

5: Bojsen R, Torbensen R, Larsen CE, Folkesson A, Regenberg B. The synthetic amphipathic peptidomimetic LTX109 is a potent fungicide that disturbs plasma membrane integrity in a sphingolipid dependent manner. PLoS One. 2013 Jul 12;8(7):e69483. doi: 10.1371/journal.pone.0069483. PubMed PMID: 23874964; PubMed Central PMCID: PMC3709891.