WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 527512
CAS#: 1333144-07-2 (HCl)
Description: SP-187, also known as N-9-DNJ and UV-4B, is an alpha-Glucosidase inhibitor potentially for the treatment of dengue fever and influenza infection. Proline-producing strains of Serratia marcescens were more osmotolerant than wild-type strains. Growth inhibition by proline analogs was significantly enhanced by increasing the osmotic stress of the medium.
MedKoo Cat#: 527512
Name: SP-187 HCl
CAS#: 1333144-07-2 (HCl)
Chemical Formula: C16H34ClNO5
Exact Mass: 319.2359
Molecular Weight: 355.9
Elemental Analysis: C, 54.00; H, 9.63; Cl, 9.96; N, 3.94; O, 22.48
Related CAS #: 1333144-07-2 (HCl) 615253-61-7 (free base)
Synonym: SP-187 HCl; SP-187 hydrochloride SP-187; SP187; SP 187; N-9-DNJ; UV-4B; N9DNJ; UV4B; N 9 DNJ; UV 4B; Iminosugar UV 4; MON-DNJ; N-9-Methoxynonyldeoxynojirimycin;
IUPAC/Chemical Name: (2R,3R,4R,5S)-2-(hydroxymethyl)-1-(9-methoxynonyl)piperidine-3,4,5-triol hydrochloride
InChi Key: LQFACEKDJKFAIT-NUSSTLEHSA-N
InChi Code: InChI=1S/C16H33NO5.ClH/c1-22-10-8-6-4-2-3-5-7-9-17-11-14(19)16(21)15(20)13(17)12-18;/h13-16,18-21H,2-12H2,1H3;1H/t13-,14+,15-,16-;/m1./s1
SMILES Code: O[C@@H]1[C@@H](CO)N(CCCCCCCCCOC)C[C@H](O)[C@H]1O.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 355.9 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Sugiura M, Kisumi M. Proline-hyperproducing strains of Serratia marcescens: enhancement of proline analog-mediated growth inhibition by increasing osmotic stress. Appl Environ Microbiol. 1985 Apr;49(4):782-6. PubMed PMID: 2860849; PubMed Central PMCID: PMC238445.
2: Baba E, Nakamura M, Ohkuma K, Kira J, Tanaka Y, Nakano S, Niho Y. A peptide-based human T cell leukemia virus type I vaccine containing T and B cell epitopes that induces high titers of neutralizing antibodies. J Immunol. 1995 Jan 1;154(1):399-412. PubMed PMID: 7527817.
