BX 048

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MedKoo CAT#: 531651

CAS#: 937395-09-0

Description: BX 048 is an active metabolite of BX 667 which is a novel P2Y12 adenosine diphosphate receptor antagonist for inhibition of platelet aggregation.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-08-15. Prices are subject to change without notice.

BX 048 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 531651
Name: BX 048
CAS#: 937395-09-0
Chemical Formula: C27H34N4O9
Exact Mass: 558.2326
Molecular Weight: 558.59
Elemental Analysis: C, 58.06; H, 6.14; N, 10.03; O, 25.78


Synonym: BX 048; BX-048; BX048.

IUPAC/Chemical Name: 5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-(1-hydroxy-2-methyl-1-oxopropan-2-yl)oxy-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid

InChi Key: MCBLPJPMVOVJCO-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H34N4O9/c1-5-39-26(38)31-12-10-30(11-13-31)24(35)18(8-9-22(32)33)29-23(34)20-15-21(40-27(3,4)25(36)37)17-7-6-16(2)14-19(17)28-20/h6-7,14-15,18H,5,8-13H2,1-4H3,(H,29,34)(H,32,33)(H,36,37)

SMILES Code: O=C(O)CCC(NC(C1=NC2=CC(C)=CC=C2C(OC(C)(C)C(O)=O)=C1)=O)C(N3CCN(C(OCC)=O)CC3)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Post JM, Alexander S, Wang YX, Vincelette J, Vergona R, Kent L, Bryant J, Sullivan ME, Dole WP, Morser J, Subramanyam B. Novel P2Y12 adenosine diphosphate receptor antagonists for inhibition of platelet aggregation (II): pharmacodynamic and pharmacokinetic characterization. Thromb Res. 2008;122(4):533-40. doi: 10.1016/j.thromres.2008.04.009. PubMed PMID: 18539312.

2: Bryant J, Post JM, Alexander S, Wang YX, Kent L, Schirm S, Tseng JL, Subramanyam B, Buckman B, Islam I, Yuan S, Sullivan ME, Snider M, Morser J. Novel P2Y12 adenosine diphosphate receptor antagonists for inhibition of platelet aggregation (I): in vitro effects on platelets. Thromb Res. 2008;122(4):523-32. doi: 10.1016/j.thromres.2008.03.026. PubMed PMID: 18495218.

3: Wang YX, Vincelette J, da Cunha V, Martin-McNulty B, Mallari C, Fitch RM, Alexander S, Islam I, Buckman BO, Yuan S, Post JM, Subramanyam B, Vergona R, Sullivan ME, Dole WP, Morser J, Bryant J. A novel P2Y(12) adenosine diphosphate receptor antagonist that inhibits platelet aggregation and thrombus formation in rat and dog models. Thromb Haemost. 2007 May;97(5):847-55. PubMed PMID: 17479197.