BWA868C

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531647

CAS#: 118675-50-6

Description: BWA868C is a DP receptor-selective antagonist. It reverses the anti-aggregatory effects of DP receptor agonists in a dose-dependent manner. Likewise, BW A868C antagonizes the accumulation of cAMP in rabbit non-pigmented ciliary epithelial cells. The Ki for BW A868C is approximately 1.7 nM.


Price and Availability

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BWA868C is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 531647
Name: BWA868C
CAS#: 118675-50-6
Chemical Formula: C25H37N3O5
Exact Mass: 459.2733
Molecular Weight: 459.59
Elemental Analysis: C, 65.34; H, 8.12; N, 9.14; O, 17.41


Synonym: BWA868C; BWA-868C; BWA 868C.

IUPAC/Chemical Name: 7-[3-[(2-cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxo-1-(phenylmethyl)imidazolidin-4-yl]heptanoic acid

InChi Key: YZJVWSKJHGEIBL-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H37N3O5/c29-22(20-13-7-4-8-14-20)17-26-28-21(15-9-1-2-10-16-23(30)31)24(32)27(25(28)33)18-19-11-5-3-6-12-19/h3,5-6,11-12,20-22,26,29H,1-2,4,7-10,13-18H2,(H,30,31)

SMILES Code: O=C(O)CCCCCCC(C(N1CC2=CC=CC=C2)=O)N(NCC(C3CCCCC3)O)C1=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Sharif NA, Williams GW, Davis TL. Pharmacology and autoradiography of human DP prostanoid receptors using [(3)H]-BWA868C, a DP receptor-selective antagonist radioligand. Br J Pharmacol. 2000 Nov;131(6):1025-38. PubMed PMID: 11082108; PubMed Central PMCID: PMC1572442.