Fagaronine chloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407365

CAS#: 52259-64-0 (chloride)

Description: Fagaronine chloride is a potent Topoisomerases I inhibitor.

Chemical Structure

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Fagaronine chloride
CAS# 52259-64-0 (chloride)
Instruction

Theoretical Analysis

MedKoo Cat#: 407365
Name: Fagaronine chloride
CAS#: 52259-64-0 (chloride)
Chemical Formula: C21H20ClNO4
Exact Mass: 0.00
Molecular Weight: 385.844
Elemental Analysis: C, 65.37; H, 5.22; Cl, 9.19; N, 3.63; O, 16.59

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 52259-65-1 (free base)   52259-64-0 (chloride)  

Synonym: Fagaronine chloride; NSC 157995; NSC-157995; NSC157995.

IUPAC/Chemical Name: 2-Hydroxy-3,8,9-trimethoxy-5-methylbenzo(c)phenanthridinium chloride

InChi Key: VVEPUJCLNRDIEQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H19NO4.ClH/c1-22-11-13-8-19(25-3)20(26-4)9-15(13)14-6-5-12-7-17(23)18(24-2)10-16(12)21(14)22;/h5-11H,1-4H3;1H

SMILES Code: C[N+]1=CC2=CC(OC)=C(OC)C=C2C3=C1C4=CC(OC)=C(O)C=C4C=C3.[Cl-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 385.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Pérez-Chiesa Y, Narváez Z. Evaluation of genotoxicity of the indenoisoquinoline analogues of fagaronine and nitidine in Drosophila melanogaster. Mutat Res. 1993 Apr;301(4):207-12. PubMed PMID: 7680753.

2: Cushman M, Mohan P. Synthesis and antitumor activity of structural analogues of the anticancer benzophenanthridine alkaloid fagaronine chloride. J Med Chem. 1985 Aug;28(8):1031-6. PubMed PMID: 4020826.

3: Janin YL, Croisy A, Riou JF, Bisagni E. Synthesis and evaluation of new 6-amino-substituted benzo[c]phenanthridine derivatives. J Med Chem. 1993 Nov 12;36(23):3686-92. PubMed PMID: 8246238.

4: Tan GT, Lee S, Lee IS, Chen J, Leitner P, Besterman JM, Kinghorn AD, Pezzuto JM. Natural-product inhibitors of human DNA ligase I. Biochem J. 1996 Mar 15;314 ( Pt 3):993-1000. PubMed PMID: 8615799; PubMed Central PMCID: PMC1217154.

5: Sethi VS. Base specificity in the inhibition of oncornavirus reverse transcriptase and cellular nucleic acid polymerases by antitumor drugs. Ann N Y Acad Sci. 1977 Mar 4;284:508-24. PubMed PMID: 81641.

6: Sethi VS. Inhibition of mammalian and oncornavirus nucleic acid polymerase activities by alkoxybenzophenanthridine alkaloids. Cancer Res. 1976 Jul;36(7 PT 1):2390-5. PubMed PMID: 58719.