S39625

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MedKoo CAT#: 407362

CAS#: 536711-20-3

Description: S39625 is an E-ring camptothecin keto analogue. S39625 is stable, potent, and selective topoisomerase I inhibitor without being substrates of drug efflux transporters. Nanomolar concentrations of S39625 induces intense and persistent histone gamma-H2AX. The chemical stability of the keto analogues and the ability of S39625 to produce high levels of persistent Top1-DNA cleavage complex and its potent antiproliferative activity against human cancer cell lines make S39625 a promising new anticancer drug candidate. Histone gamma-H2AX could be used as a biomarker for the upcoming clinical trials of S39625.

Chemical Structure

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S39625
CAS# 536711-20-3
Instruction

Theoretical Analysis

MedKoo Cat#: 407362
Name: S39625
CAS#: 536711-20-3
Chemical Formula: C25H22N2O5
Exact Mass: 430.15
Molecular Weight: 430.460
Elemental Analysis: C, 69.76; H, 5.15; N, 6.51; O, 18.58

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: S39625; S-39625; S 39625.

IUPAC/Chemical Name: (S)-13-cyclobutyl-7-ethyl-7-hydroxy-9,12-dihydro-7H-cyclopenta[6,7]indolizino[1,2-b][1,3]dioxolo[4,5-g]quinoline-8,10-dione

InChi Key: BSNSKRNANVCWQN-VWLOTQADSA-N

InChi Code: InChI=1S/C25H22N2O5/c1-2-25(30)16-8-18-23-15(10-27(18)24(29)13(16)7-21(25)28)22(12-4-3-5-12)14-6-19-20(32-11-31-19)9-17(14)26-23/h6,8-9,12,30H,2-5,7,10-11H2,1H3/t25-/m0/s1

SMILES Code: O=C(C1)[C@](O)(CC)C2=C1C(N3CC4=C(C5CCC5)C6=CC(OCO7)=C7C=C6N=C4C3=C2)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 430.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Takagi K, Dexheimer TS, Redon C, Sordet O, Agama K, Lavielle G, Pierré A,
Bates SE, Pommier Y. Novel E-ring camptothecin keto analogues (S38809 and S39625)
are stable, potent, and selective topoisomerase I inhibitors without being
substrates of drug efflux transporters. Mol Cancer Ther. 2007 Dec;6(12 Pt
1):3229-38. PubMed PMID: 18089716.