WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530477

CAS#: 1998197-39-9

Description: ZCZ011 is a positive allosteric modulator of the cannabinoid CB1 receptor. ZCZ011 potentiated binding of [(3)H]CP55,940 to the CB1 receptor as well as enhancing AEA-stimulated [(35)S]GTPγS binding in mouse brain membranes and β-arrestin recruitment and ERK phosphorylation in hCB1 cells. In the whole animal, ZCZ011 is brain penetrant, increased the potency of these orthosteric agonists in mouse behavioral assays indicative of cannabimimetic activity, including antinociception, hypothermia, catalepsy, locomotor activity, and in the drug discrimination paradigm. ZCZ011 acts as a CB1 PAM and provide the first proof of principle that CB1 PAMs offer a promising strategy to treat neuropathic and inflammatory pain with minimal or no cannabimimetic side effects.

Chemical Structure

CAS# 1998197-39-9

Theoretical Analysis

MedKoo Cat#: 530477
Name: ZCZ011
CAS#: 1998197-39-9
Chemical Formula: C21H18N2O2S
Exact Mass: 362.1089
Molecular Weight: 362.447
Elemental Analysis: C, 69.59; H, 5.01; N, 7.73; O, 8.83; S, 8.85

Price and Availability

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5.0mg USD 295.0 2 Weeks
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Synonym: ZCZ011; ZCZ-011; ZCZ 011.

IUPAC/Chemical Name: 6-methyl-3-(2-nitro-1-(thiophen-2-yl)ethyl)-2-phenyl-1H-indole


InChi Code: InChI=1S/C21H18N2O2S/c1-14-9-10-16-18(12-14)22-21(15-6-3-2-4-7-15)20(16)17(13-23(24)25)19-8-5-11-26-19/h2-12,17,22H,13H2,1H3

SMILES Code: O=[N+](CC(C1=C(C2=CC=CC=C2)NC3=C1C=CC(C)=C3)C4=CC=CS4)[O-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 362.447 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Ignatowska-Jankowska BM, Baillie GL, Kinsey S, Crowe M, Ghosh S, Owens RA,
Damaj IM, Poklis J, Wiley JL, Zanda M, Zanato C, Greig IR, Lichtman AH, Ross RA.
A Cannabinoid CB1 Receptor-Positive Allosteric Modulator Reduces Neuropathic Pain
in the Mouse with No Psychoactive Effects. Neuropsychopharmacology. 2015
Dec;40(13):2948-59. doi: 10.1038/npp.2015.148. PubMed PMID: 26052038; PubMed
Central PMCID: PMC4864630.


5.0mg / USD 295.0