Nifenalol | CAS#5704-60-9 | 7413-36-7 | beta-adrenergic receptor antagonist

Nifenalol HCl
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 329523

CAS#: 5704-60-9 (HCl)

Description: Nifenalol, also known as INPEA, is a new beta-adrenergic receptor antagonist.

Chemical Structure

Nifenalol HCl

CAS# 5704-60-9 (HCl)

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 329523
Name: Nifenalol HCl
CAS#: 5704-60-9 (HCl)
Chemical Formula: C11H17ClN2O3
Exact Mass: 0.00
Molecular Weight: 260.718
Elemental Analysis: C, 50.68; H, 6.57; Cl, 13.60; N, 10.74; O, 18.41

Price and Availability

Size	Price	Availability	Quantity
100mg	USD 350
200mg	USD 550
500mg	USD 1050
1g	USD 1950
2g	USD 3650
5g	USD 5450
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 5704-60-9 (HCl) 7413-36-7 (free base)

Synonym: Nifenalol; Nifenalol HCl; INPEA.

IUPAC/Chemical Name: 2-(Isopropylamino)-1-(p-nitrophenyl)ethanol hydrochloride

InChi Key: STGOXRVTUNXXLQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H16N2O3.ClH/c1-8(2)12-7-11(14)9-3-5-10(6-4-9)13(15)16;/h3-6,8,11-12,14H,7H2,1-2H3;1H

SMILES Code: O=[N+](C1=CC=C(C(O)CNC(C)C)C=C1)[O-].[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Related CAS# 5704-60-9 (Nifenalol HCl) 7413-36-7 (Nifenalol free base)

Product Data:

Product Data

Instruction:

View handling instruction

Biological target:	Nifenalol, also known as INPEA, is a new beta-adrenergic receptor antagonist.
In vitro activity:	TBD
In vivo activity:	TBD

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMF	30.0	115.07
	DMSO	30.0	115.07
	Ethanol	5.0	19.18
	PBS (pH 7.2)	10.0	38.36

Preparing Stock Solutions

The following data is based on the product molecular weight 260.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	TBD
In vitro protocol:	TBD
In vivo protocol:	TBD

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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1: Rabast U, Kasper H, Schönborn J, Knechtel B. [Blood glucose concentration and insulin activity in serum after administration of the beta receptor blockader nifenalol-HC1 (INPEA). Studies in metabolically healthy people and diabetics]. Ther Ggw. 1977 Jun;116(6):1162-74. German. PubMed PMID: 578017.

2: Nishimura T, Kita S, Abiko Y. Effects of 1-(4-nitrophenyl)-2-isopropylaminoethanol (INPEA) and propranolol and their dextro-isomers on hemodynamic and metabolic responses to isoproterenol in dogs. J Pharmacol Exp Ther. 1983 Aug;226(2):595-602. PubMed PMID: 6688273.

3: Hasslacher C, Wahl P, Riemer G. [Influence of the beta-receptor blocker nifenalol on insulin secretion in normal subjects and diabetic patients (author's transl)]. Arzneimittelforschung. 1977 Feb;27(2):426-9. German. PubMed PMID: 577165.

4: Ichiyama M, Sada S, Takahashi Y, Sada H, Ban T. Effects of bucumolol, nadolol and nifenalol on maximum upstroke velocity of action potential in guinea pig papillary muscles. Naunyn Schmiedebergs Arch Pharmacol. 1986 Mar;332(3):297-304. PubMed PMID: 2872598.

5: Capasso F, Sorrentino L. Sensitization by (+) Inpea of rat stomach strip contraction induced by PGE2 or pleural exudates. Pharmacol Res Commun. 1981 Jul;13(7):705-9. PubMed PMID: 6944701.

6: Sánchez-Cuadrado MC, Boada J, Bayo JM. [Action of propranolol, nifenalol, and pindolol on the lipolytic effect of adrenaline in the rat epididymis]. Arch Farmacol Toxicol. 1981 Apr;7(1):181-2. Spanish. PubMed PMID: 6895689.

7: Singh BN, Williams EM. Effects on cardiac muscle of the -adrenoceptor blocking drugs INPEA and LB46 in relation to their local anaesthetic action on nerve. Br J Pharmacol. 1971 Sep;43(1):10-22. PubMed PMID: 4400181; PubMed Central PMCID: PMC1665935.

8: Somani P. Study on some selective beta-adrenoreceptor blocking effects of 1-(4-nitrophenyl)-1-hydroxy-2-methyl isoproylaminoethane (alpha-methyl INPEA). Br J Pharmacol. 1969 Nov;37(3):609-17. PubMed PMID: 4390678; PubMed Central PMCID: PMC1703724.

9: Pandhi P, Sharma PL. Potentiating effect of (+) INPEA on prostaglandin analogue evoked contractions of isolated rat uterus. Indian J Med Res. 1983 Mar;77:391-4. PubMed PMID: 6688239.

10: Garg SK, Rajkumar K. Effect of (+) INPEA, (+) sotalol and deoxysotalol on the in vitro production of prostaglandins E and F by the rat uterus. Indian J Med Res. 1980 Apr;71:641-4. PubMed PMID: 6893041.

11: Khetarpal VK, Sharma PL. Comparative effects of (+)- and (-)-isomers of propranolol and INPEA on (+)-tubocurarine- and succinylcholine-induced neuromuscular blockade. Eur J Pharmacol. 1975 Sep-Oct;33(2):325-35. PubMed PMID: 1242378.

12: Harms HH, Zaagsma J, de Vente J. Differentiation of beta-adrenoceptors in right atrium, diaphragm and adipose tissue of the rat, using stereoisomers of propranolol, alprenolol, nifenalol and practolol. Life Sci. 1977 Jul 1;21(1):123-8. PubMed PMID: 196150.

13: Rao VS, Sharma PL. Potentiation of oxytocin and prostaglandins-evoked responses by (+) INPEA on isolated rat uterus: its specificity and selectivity. Jpn J Pharmacol. 1974 Dec;24(6):893-901. PubMed PMID: 4156875.

14: Murmann W, Rumore G, Gamba A. Pharmacological properties of 1-(4'-nitrophenyl)-2-isopropylamino-ethanol (INPEA), a new beta-adrenergic receptor antagonist. V. Effects of the optical isomers D(minus) and L(plus) INPEA on heart rate, oxygen consumption and body temperature and on the cardiac and metabolic effects of adrenaline and noradrenaline in urethane-anesthetized rats. Boll Chim Farm. 1967 Apr;106(4):251-68. PubMed PMID: 5613020.

15: Dorfmüller P, Günther S, Ghigna MR, Thomas de Montpréville V, Boulate D, Paul JF, Jaïs X, Decante B, Simonneau G, Dartevelle P, Humbert M, Fadel E, Mercier O. Microvascular disease in chronic thromboembolic pulmonary hypertension: a role for pulmonary veins and systemic vasculature. Eur Respir J. 2014 Nov;44(5):1275-88. doi: 10.1183/09031936.00169113. PubMed PMID: 25142477.

16: Del Tacca M, Bertelli A, Mazzanti L, Stacchini B, Balsamo A, Crotti P, Macchia B, Macchia F. Conformational effects on the activity of drugs. 5. Pharmacological properties of 2-(p-nitrophenyl)-4-isopropylmorpholine, a cyclic analog of INPEA. J Med Chem. 1975 Aug;18(8):836-8. PubMed PMID: 1174140.

17: Abiko Y, Minamidate A, Ito M. Comparison of the effects of pronethalol, MJ 1999, D(-) INPEA and L(+) INPEA on the pressor response to acethycholine in atropinized dogs. Arch Int Pharmacodyn Ther. 1969 May;179(1):130-6. PubMed PMID: 4390661.

18: Mazurkiewicz IM. The effects of L (+) INPEA, dl-INPEA and of combined parasympathetic and sympathetic blockade on the cardiovascular responses to noradrenaline. Arch Int Pharmacodyn Ther. 1968 Oct;175(2):280-94. PubMed PMID: 5702948.

19: Murmann W, Gamba A. Pharmacological properties of 1-(4'-nitrophenyl)-2-isopropylamino-ethanol (INPEA), a new beta-adrenergic receptor antagonist. IV. Effects of the optical isomers D (minus) and L (plus) INPEA on the arterial pressure and on the pressor responses to noradrenaline, adrenaline and isoproterenol in urethan-anesthetised rats. Boll Chim Farm. 1967 Feb;106(2):101-8. PubMed PMID: 5608202.

20: Nag DP, Chopra SC, Sharma PL. Comparative study of propranolol, sotalol and INPEA in ouabain-induced cardiac arrhythmias. Indian J Med Res. 1977 Dec;66(6):1015-21. PubMed PMID: 580429.

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