Vintoperol

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MedKoo CAT#: 530014

CAS#: 106498-99-1

Description: Vintoperol is a calcium channel antagonist potentially for the treatment of arterial occlusive disease and peripheral artery disease.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-08-10. Prices are subject to change without notice.

Vintoperol is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530014
Name: Vintoperol
CAS#: 106498-99-1
Chemical Formula: C18H24N2O
Exact Mass: 284.19
Molecular Weight: 284.4
Elemental Analysis: C, 76.02; H, 8.51; N, 9.85; O, 5.63


Synonym: Vintoperol, RGH-2981, RT-3003, RGH2981, RT3003, RGH 2981, RT 3003

IUPAC/Chemical Name: ((1S,12bS)-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-1-yl)methanol

InChi Key: BKRBRZLECKMEBD-QZTJIDSGSA-N

InChi Code: InChI=1S/C18H24N2O/c1-2-18(12-21)9-5-10-20-11-8-14-13-6-3-4-7-15(13)19-16(14)17(18)20/h3-4,6-7,17,19,21H,2,5,8-12H2,1H3/t17-,18-/m1/s1

SMILES Code: CC[C@]1(CO)CCCN2[C@@H]1C3=C(C4=CC=CC=C4N3)CC2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Yoshitsugu H, Fukuhara T, Ishibashi M, Nanbo T, Kagi N. Key fragments for identification of positional isomer pair in glucuronides from the hydroxylated metabolites of RT-3003 (Vintoperol) by liquid chromatography/electrospray ionization mass spectrometry. J Mass Spectrom. 1999 Oct;34(10):1063-8. PubMed PMID: 10510429.

2: Csomor K, Kárpáti E. Effect of vintoperol on platelet aggregation and experimental thrombosis. Arzneimittelforschung. 1994 Jan;44(1):36-40. PubMed PMID: 8135876.

3: Tkachenko MN, Sagach VF, Bazilyuk OV, Shapoval MV. Involvement of endothelium in vasodilating effects of vintoperol. J Cardiovasc Pharmacol. 1992;20 Suppl 12:S90-3. PubMed PMID: 1282997.

4: Sahach VF, Tkachenko MM, Bazyliuk OV. [The role of the endothelium in the vascular effects of vintoperol]. Fiziol Zh. 1992 May-Jun;38(3):32-9. Ukrainian. PubMed PMID: 1499759.

5: Xu R, Liu N, Xu X, Kong B. Antioxidative effects of whey protein on peroxide-induced cytotoxicity. J Dairy Sci. 2011 Aug;94(8):3739-46. doi: 10.3168/jds.2010-3891. PubMed PMID: 21787910.

6: Szombathelyi Z, Kárpáti E, Kalaus G, Szabó L, Szántay C. Vasodilator and angioprotective activity of 1-ethyl-1-hydroxyalkyl-octahydroindolo[2,3a]quinolizine derivates. Arzneimittelforschung. 1991 Jun;41(6):621-5. PubMed PMID: 1930350.

7: Kárpáti E, Bíró K, Kukorelli T. [Investigation of vasoactive agents with indole skeletons at Richter Ltd]. Acta Pharm Hung. 2002;72(1):25-36. Hungarian. PubMed PMID: 12426785.

8: Kaburagi T, Yoshitsugu H, Uekusa H, Ishibashi M, Nanbo T. Identification and clearance involved in the formation of glucuronides of RT-3003, a new peripheral blood flow enhancer, and its metabolite in rats. Biol Pharm Bull. 2000 Jan;23(1):128-31. PubMed PMID: 10706427.

9: Szombathelyi Z, Kárpáti E, Till A. Comparative in vitro study of RGH-2981, a new peripheral blood flow enhancer on animal and pathological human arteries. Pol J Pharmacol Pharm. 1989 Nov-Dec;41(6):591-5. PubMed PMID: 2485906.