JK184
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406989

CAS#: 315703-52-7

Description: JK-184 is a potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM). JK184 can specially inhibit Gli in the Hedgehog (Hh) pathway, which showed great promise for cancer therapeutics.


Chemical Structure

img
JK184
CAS# 315703-52-7

Theoretical Analysis

MedKoo Cat#: 406989
Name: JK184
CAS#: 315703-52-7
Chemical Formula: C19H18N4OS
Exact Mass: 350.1201
Molecular Weight: 350.44
Elemental Analysis: C, 65.12; H, 5.18; N, 15.99; O, 4.57; S, 9.15

Price and Availability

Size Price Availability Quantity
50.0mg USD 450.0 2 Weeks
100.0mg USD 750.0 2 Weeks
200.0mg USD 1250.0 2 Weeks
500.0mg USD 1950.0 2 Weeks
1.0g USD 2950.0 2 Weeks
2.0g USD 5250.0 2 Weeks
Bulk inquiry

Synonym: JK-184; JK 184; JK184.

IUPAC/Chemical Name: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine

InChi Key: ROYXIPOUVGDTAO-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H18N4OS/c1-3-24-15-9-7-14(8-10-15)21-19-22-16(12-25-19)18-13(2)20-17-6-4-5-11-23(17)18/h4-12H,3H2,1-2H3,(H,21,22)

SMILES Code: CC1=C(C2=CSC(NC3=CC=C(OCC)C=C3)=N2)N4C=CC=CC4=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 350.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Zhang N, Liu S, Wang N, Deng S, Song L, Wu Q, Liu L, Su W, Wei Y, Xie Y, Gong
C. Biodegradable polymeric micelles encapsulated JK184 suppress tumor growth
through inhibiting Hedgehog signaling pathway. Nanoscale. 2015 Feb
14;7(6):2609-24. doi: 10.1039/c4nr06300g. PubMed PMID: 25581613.

2: Cupido T, Rack PG, Firestone AJ, Hyman JM, Han K, Sinha S, Ocasio CA, Chen JK.
The imidazopyridine derivative JK184 reveals dual roles for microtubules in
Hedgehog signaling. Angew Chem Int Ed Engl. 2009;48(13):2321-4. doi:
10.1002/anie.200805666. PubMed PMID: 19222062.

3: Colavito SA, Zou MR, Yan Q, Nguyen DX, Stern DF. Significance of
glioma-associated oncogene homolog 1 (GLI1) expression in claudin-low breast
cancer and crosstalk with the nuclear factor kappa-light-chain-enhancer of
activated B cells (NFκB) pathway. Breast Cancer Res. 2014 Sep 25;16(5):444. doi:
10.1186/s13058-014-0444-4. PubMed PMID: 25252859; PubMed Central PMCID:
PMC4303124.

4: Lee J, Wu X, Pasca di Magliano M, Peters EC, Wang Y, Hong J, Hebrok M, Ding S,
Cho CY, Schultz PG. A small-molecule antagonist of the hedgehog signaling
pathway. Chembiochem. 2007 Nov 5;8(16):1916-9. PubMed PMID: 17886323.

JK184

50.0mg / USD 450.0