VU0467485
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MedKoo CAT#: 530453

CAS#: 1451994-10-7

Description: VU0467485, also known as AZ13713945, is a potent, selective, and orally bioavailable muscarinic acetylcholine receptor 4 (M4) positive allosteric modulators (PAMs). VU0467485 represents a major advance in the field, as the first potent M4 PAM to overcome major species differences in potency while maintaining high selectivity versus M2 (rat, dog, cyno, and human EC50s > 30 μM), CNS penetration, and in vivo efficacy. VU0467485 showed robust efficacy in behavioral models that was evaluated as a preclinical candidate.


Price and Availability

Size Price Shipping out time Quantity
10mg USD 380 2 Weeks
50mg USD 1290 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-26. Prices are subject to change without notice.

VU 0467485, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530453
Name: VU0467485
CAS#: 1451994-10-7
Chemical Formula: C17H17FN4O2S
Exact Mass: 360.1056
Molecular Weight: 360.4074
Elemental Analysis: C, 56.65; H, 4.75; F, 5.27; N, 15.55; O, 8.88; S, 8.90


Synonym: VU 0467485, VU-0467485, VU0467485, AZ13713945, AZ-13713945, AZ 13713945

IUPAC/Chemical Name: 5-amino-N-(3-fluoro-4-methoxybenzyl)-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide

InChi Key: VFNHDIWHQGVWLL-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H17FN4O2S/c1-8-9(2)21-22-17-13(8)14(19)15(25-17)16(23)20-7-10-4-5-12(24-3)11(18)6-10/h4-6H,7,19H2,1-3H3,(H,20,23)

SMILES Code: O=C(C1=C(N)C2=C(C)C(C)=NN=C2S1)NCC3=CC=C(OC)C(F)=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1. Discovery of VU0467485/AZ13713945: An M4 PAM Evaluated as a Preclinical Candidate for the Treatment of Schizophrenia Michael R. WoodMeredith J. NoetzelBruce J. MelanconMichael S. PoslusneyKellie D. NanceMiguel A. HurtadoVincent B. LuscombeRebecca L. WeinerAlice L. RodriguezAtin LamsalSichen ChangMichael BubserAnna L. BlobaumDarren W. EngersColleen M. NiswenderCarrie K. JonesNicholas J. BrandonMichael W. WoodMark E. DugganP. Jeffrey ConnThomas M. Bridgesand Craig W. Lindsley Publication Date (Web): December 16, 2016 (Letter) DOI: 10.1021/acsmedchemlett.6b00461