AC261066
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531388

CAS#: 870773-76-5

Description: AC261066 is a retinoic acid receptor β2 agonist.


Chemical Structure

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AC261066
CAS# 870773-76-5

Theoretical Analysis

MedKoo Cat#: 531388
Name: AC261066
CAS#: 870773-76-5
Chemical Formula: C17H20FNO4S
Exact Mass: 353.1097
Molecular Weight: 353.4084
Elemental Analysis: C, 57.78; H, 5.70; F, 5.38; N, 3.96; O, 18.11; S, 9.07

Price and Availability

Size Price Availability Quantity
25.0mg USD 450.0 2 Weeks
50.0mg USD 750.0 2 Weeks
100.0mg USD 1250.0 2 Weeks
200.0mg USD 2050.0 2 Weeks
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Synonym: AC261066; AC-261066; AC 261066;

IUPAC/Chemical Name: 4-[4-(2-butoxyethoxy)-5-methyl-1,3-thiazol-2-yl]-2-fluorobenzoic acid

InChi Key: HSAOETBFVAWNRP-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H20FNO4S/c1-3-4-7-22-8-9-23-15-11(2)24-16(19-15)12-5-6-13(17(20)21)14(18)10-12/h5-6,10H,3-4,7-9H2,1-2H3,(H,20,21)

SMILES Code: O=C(O)C1=CC=C(C2=NC(OCCOCCCC)=C(C)S2)C=C1F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 353.4084 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Trasino SE, Tang XH, Jessurun J, Gudas LJ. A retinoic acid receptor β2 agonist reduces hepatic stellate cell activation in nonalcoholic fatty liver disease. J Mol Med (Berl). 2016 Oct;94(10):1143-1151. PubMed PMID: 27271256; PubMed Central PMCID: PMC5053866.

2: Trasino SE, Tang XH, Jessurun J, Gudas LJ. Retinoic acid receptor β2 agonists restore glycaemic control in diabetes and reduce steatosis. Diabetes Obes Metab. 2016 Feb;18(2):142-51. doi: 10.1111/dom.12590. PubMed PMID: 26462866; PubMed Central PMCID: PMC4948868.

3: Lund BW, Piu F, Gauthier NK, Eeg A, Currier E, Sherbukhin V, Brann MR, Hacksell U, Olsson R. Discovery of a potent, orally available, and isoform-selective retinoic acid beta2 receptor agonist. J Med Chem. 2005 Dec 1;48(24):7517-9. PubMed PMID: 16302793.

AC261066

25.0mg / USD 450.0