Befiradol (free base)

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MedKoo CAT#: 530114

CAS#: 208110-64-9

Description: Befiradol (free base) is a highly selective and potent 5-HT1A receptor agonist potentially for the treatment of drug-induced dyskinesia in patients with Parkinson's disease.

Price and Availability

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Pricing updated 2020-10-20. Prices are subject to change without notice.

Befiradol (free base) is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 530114
Name: Befiradol (free base)
CAS#: 208110-64-9
Chemical Formula: C20H22ClF2N3O
Exact Mass: 393.14
Molecular Weight: 393.86
Elemental Analysis: C, 60.99; H, 5.63; Cl, 9.00; F, 9.65; N, 10.67; O, 4.06

Synonym: F-13640; F13640; F 13640; NLX-112; NLX112; NLX 112

IUPAC/Chemical Name: (3-chloro-4-fluorophenyl)-[4-fluoro-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone


InChi Code: InChI=1S/C20H22ClF2N3O/c1-14-3-6-18(24-12-14)25(2)13-20(23)7-9-26(10-8-20)19(27)15-4-5-17(22)16(21)11-15/h3-6,11-12H,7-10,13H2,1-2H3

SMILES Code: O=C(C1=CC=C(F)C(Cl)=C1)N2CCC(CN(C3=NC=C(C)C=C3)C)(F)CC2

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Additional Information

Related CAS#
208110-64-9(Befiradol free base)
208110-65-0(Befiradol Fumarate)


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9: Colpaert FC. 5-HT(1A) receptor activation: new molecular and neuroadaptive mechanisms of pain relief. Curr Opin Investig Drugs. 2006 Jan;7(1):40-7. Review. PubMed PMID: 16425670.

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18: Wu WP, Hao JX, Xu XJ, Wiesenfeld-Hallin Z, Koek W, Colpaert FC. The very-high-efficacy 5-HT1A receptor agonist, F 13640, preempts the development of allodynia-like behaviors in rats with spinal cord injury. Eur J Pharmacol. 2003 Oct 8;478(2-3):131-7. PubMed PMID: 14575797.

19: Pauwels PJ, Colpaert FC. Ca2+ responses in Chinese hamster ovary-K1 cells demonstrate an atypical pattern of ligand-induced 5-HT1A receptor activation. J Pharmacol Exp Ther. 2003 Nov;307(2):608-14. PubMed PMID: 12970382.

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