AC-186
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531386

CAS#: 1421854-16-1

Description: AC-186 is reported as a selective nonsteroidal estrogen receptor agonist.


Chemical Structure

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AC-186
CAS# 1421854-16-1

Theoretical Analysis

MedKoo Cat#: 531386
Name: AC-186
CAS#: 1421854-16-1
Chemical Formula: C18H17F3O
Exact Mass: 306.1231
Molecular Weight: 306.3282
Elemental Analysis: C, 70.58; H, 5.59; F, 18.61; O, 5.22

Price and Availability

Size Price Availability Quantity
10.0mg USD 385.0 2 Weeks
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Synonym: AC-186; AC 186; AC186.

IUPAC/Chemical Name: 4-[4,4-difluoro-1-(2-fluorophenyl)cyclohexyl]phenol

InChi Key: HSMUKSLNDJOZQG-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H17F3O/c19-16-4-2-1-3-15(16)17(9-11-18(20,21)12-10-17)13-5-7-14(22)8-6-13/h1-8,22H,9-12H2

SMILES Code: OC1=CC=C(C2(C3=CC=CC=C3F)CCC(F)(F)CC2)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 306.3282 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Shimada M, Kigawa J, Nishimura R, Hiura M, Hatae M, Takehara K, Sato A, Kurachi H, Mizunuma H, Sugiyama T. Comparison of the outcome between cervical adenocarcinoma and squamous cell carcinoma patients with adjuvant radiotherapy after radical surgery: SGSG/TGCU Intergroup Surveillance. J Clin Oncol. 2009 May 20;27(15_suppl):5585. PubMed PMID: 27962392.

2: Ma JN, McFarland K, Olsson R, Burstein ES. Estrogen Receptor Beta Selective Agonists as Agents to Treat Chemotherapeutic-Induced Neuropathic Pain. ACS Chem Neurosci. 2016 Sep 21;7(9):1180-7. doi: 10.1021/acschemneuro.6b00183. PubMed PMID: 27456785.

3: Price EW, Orvig C. Matching chelators to radiometals for radiopharmaceuticals. Chem Soc Rev. 2014 Jan 7;43(1):260-90. doi: 10.1039/c3cs60304k. Review. PubMed PMID: 24173525.

4: George S, Petit GH, Gouras GK, Brundin P, Olsson R. Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer's disease. ACS Chem Neurosci. 2013 Dec 18;4(12):1537-48. doi: 10.1021/cn400133s. PubMed PMID: 24020966; PubMed Central PMCID: PMC3867967.

5: McFarland K, Price DL, Davis CN, Ma JN, Bonhaus DW, Burstein ES, Olsson R. AC-186, a selective nonsteroidal estrogen receptor β agonist, shows gender specific neuroprotection in a Parkinson's disease rat model. ACS Chem Neurosci. 2013 Sep 18;4(9):1249-55. doi: 10.1021/cn400132u. PubMed PMID: 23898966; PubMed Central PMCID: PMC3778431.

AC-186

10.0mg / USD 385.0