A839977
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531368

CAS#: 870061-27-1

Description: A839977 is a P2X7R antagonist.


Chemical Structure

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A839977
CAS# 870061-27-1

Theoretical Analysis

MedKoo Cat#: 531368
Name: A839977
CAS#: 870061-27-1
Chemical Formula: C19H14Cl2N6O
Exact Mass: 412.0606
Molecular Weight: 413.262
Elemental Analysis: C, 55.22; H, 3.41; Cl, 17.16; N, 20.34; O, 3.87

Price and Availability

Size Price Availability Quantity
5.0mg USD 230.0 2 Weeks
10.0mg USD 370.0 2 Weeks
25.0mg USD 620.0 2 Weeks
50.0mg USD 890.0 2 Weeks
100.0mg USD 1295.0 2 Weeks
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Synonym: A839977

IUPAC/Chemical Name: 1-(2,3-dichlorophenyl)-N-{[2-(pyridin-2-yloxy)phenyl]methyl}-1H-1,2,3,4-tetrazol-5-amine

InChi Key: GMVNBKZQJFRFAR-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H14Cl2N6O/c20-14-7-5-8-15(18(14)21)27-19(24-25-26-27)23-12-13-6-1-2-9-16(13)28-17-10-3-4-11-22-17/h1-11H,12H2,(H,23,24,26)

SMILES Code: ClC1=C(Cl)C(N2N=NN=C2NCC3=CC=CC=C3OC4=NC=CC=C4)=CC=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 413.262 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Yang YL, Sun W, Peng C, Zhang XY, Yang XH. [Research progress of selective mGluR1 antagonists]. Yao Xue Xue Bao. 2011 Oct;46(10):1167-72. Review. Chinese. PubMed PMID: 22242445.

2: Zhu CZ, Baker S, EI-Kouhen O, Lehto SG, Hollingsworth PR, Gauvin DM, Hernandez G, Zheng G, Chang R, Moreland RB, Stewart AO, Brioni JD, Honore P. Analgesic activity of metabotropic glutamate receptor 1 antagonists on spontaneous post-operative pain in rats. Eur J Pharmacol. 2008 Feb 12;580(3):314-21. PubMed PMID: 18054908.

3: Zheng GZ, Bhatia P, Daanen J, Kolasa T, Patel M, Latshaw S, El Kouhen OF, Chang R, Uchic ME, Miller L, Nakane M, Lehto SG, Honore MP, Moreland RB, Brioni JD, Stewart AO. Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists. J Med Chem. 2005 Nov 17;48(23):7374-88. PubMed PMID: 16279797.

4: Falk S, Schwab SD, Frøsig-Jørgensen M, Clausen RP, Dickenson AH, Heegaard AM. P2X7 receptor-mediated analgesia in cancer-induced bone pain. Neuroscience. 2015 Apr 16;291:93-105. doi: 10.1016/j.neuroscience.2015.02.011. PubMed PMID: 25686524.

A839977

5.0mg / USD 230.0