WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406961
CAS#: 1454585-06-8
Description: SR-3029 is a potent and selective casein kinase 1δ/1ε (CK1δ/ε) inhibitor with potent antiproliferative properties SR-3029 shoed IC50:= 97 nM in MTT assays against the human A375 melanoma cell line and have physical, in vitro and in vivo PK properties suitable for use in proof of principle animal xenograft studies against human cancer cell lines.
MedKoo Cat#: 406961
Name: SR-3029
CAS#: 1454585-06-8
Chemical Formula: C23H19F3N8O
Exact Mass: 480.1634
Molecular Weight: 480.4552
Elemental Analysis: C, 57.50; H, 3.99; F, 11.86; N, 23.32; O, 3.33
Synonym: SR-3029; SR 3029; SR3029.
IUPAC/Chemical Name: (6,7-Difluoro-1H-benzoimidazol-2-ylmethyl)-[9-(3-fluoro-phenyl)-2-morpholin-4-yl-9H-purin-6-yl]-amine
InChi Key: CEBMEQPREMCWOL-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H19F3N8O/c24-13-2-1-3-14(10-13)34-12-28-20-21(31-23(32-22(20)34)33-6-8-35-9-7-33)27-11-17-29-16-5-4-15(25)18(26)19(16)30-17/h1-5,10,12H,6-9,11H2,(H,29,30)(H,27,31,32)
SMILES Code: FC1=CC(N2C=NC3=C(NCC4=NC5=CC=C(F)C(F)=C5N4)N=C(N6CCOCC6)N=C23)=CC=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 480.4552 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Rosenberg LH, Lafitte M, Quereda V, Grant W, Chen W, Bibian M, Noguchi Y,
Fallahi M, Yang C, Chang JC, Roush WR, Cleveland JL, Duckett DR. Therapeutic
targeting of casein kinase 1δ in breast cancer. Sci Transl Med. 2015 Dec
16;7(318):318ra202. doi: 10.1126/scitranslmed.aac8773. PubMed PMID: 26676609;
PubMed Central PMCID: PMC4809734.
2: Bibian M, Rahaim RJ, Choi JY, Noguchi Y, Schürer S, Chen W, Nakanishi S, Licht
K, Rosenberg LH, Li L, Feng Y, Cameron MD, Duckett DR, Cleveland JL, Roush WR.
Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with
potent antiproliferative properties. Bioorg Med Chem Lett. 2013 Aug
1;23(15):4374-80. doi: 10.1016/j.bmcl.2013.05.075. PubMed PMID: 23787102; PubMed
Central PMCID: PMC3783656.
