BX-517
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MedKoo CAT#: 530426

CAS#: 850717-64-5

Description: BX-517, also known as PDK1 inhibitor2, is a potent and selective PDK1 inhibitor.


Price and Availability

Size Price Shipping out time Quantity
10mg USD 110 Same day
25mg USD 190 Same day
50mg USD 350 Same day
100mg USD 550 Same day
200mg USD 950 Same day
500mg USD 1850 Same day
1g USD 2950 Same day
2g USD 5250 Same day
Inquire bulk and customized quantity

Pricing updated 2020-09-27. Prices are subject to change without notice.

BX-517, purity > 98%, is in stock. The same day shipping out after order is received


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530426
Name: BX-517
CAS#: 850717-64-5
Chemical Formula: C15H14N4O2
Exact Mass: 282.1117
Molecular Weight: 282.303
Elemental Analysis: C, 63.82; H, 5.00; N, 19.85; O, 11.33


Synonym: BX-517; BX 517; BX517; PDK1 inhibitor2.

IUPAC/Chemical Name: (Z)-N-(3-(1-(1H-pyrrol-2-yl)ethylidene)-2-hydroxy-3H-indol-5-yl)carbamimidic acid

InChi Key: DFURSNCTQGJRRX-JYRVWZFOSA-N

InChi Code: InChI=1S/C15H14N4O2/c1-8(11-3-2-6-17-11)13-10-7-9(18-15(16)21)4-5-12(10)19-14(13)20/h2-7,17H,1H3,(H,19,20)(H3,16,18,21)/b13-8-

SMILES Code: OC(NC1=CC2=C(N=C(O)/C2=C(C3=CC=CN3)/C)C=C1)=N


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


Additional Information


References

1: Islam I, Brown G, Bryant J, Hrvatin P, Kochanny MJ, Phillips GB, Yuan S, Adler M, Whitlow M, Lentz D, Polokoff MA, Wu J, Shen J, Walters J, Ho E, Subramanyam B, Zhu D, Feldman RI, Arnaiz DO. Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: optimization of BX-517. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3819-25. PubMed PMID: 17544272.

2: Islam I, Bryant J, Chou YL, Kochanny MJ, Lee W, Phillips GB, Yu H, Adler M, Whitlow M, Ho E, Lentz D, Polokoff MA, Subramanyam B, Wu JM, Zhu D, Feldman RI, Arnaiz DO. Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3814-8. PubMed PMID: 17531483.