BX-517
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530426

CAS#: 850717-64-5

Description: BX-517, also known as PDK1 inhibitor2, is a potent and selective PDK1 inhibitor.


Price and Availability

Size
Price

10mg
USD 110
100mg
USD 550
1g
USD 2950
Size
Price

25mg
USD 190
200mg
USD 950
2g
USD 3850
Size
Price

50mg
USD 350
500mg
USD 1850

BX-517, purity > 98%, is in stock. The same day shipping out after order is received


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530426
Name: BX-517
CAS#: 850717-64-5
Chemical Formula: C15H14N4O2
Exact Mass: 282.1117
Molecular Weight: 282.303
Elemental Analysis: C, 63.82; H, 5.00; N, 19.85; O, 11.33


Synonym: BX-517; BX 517; BX517; PDK1 inhibitor2.

IUPAC/Chemical Name: (Z)-N-(3-(1-(1H-pyrrol-2-yl)ethylidene)-2-hydroxy-3H-indol-5-yl)carbamimidic acid

InChi Key: DFURSNCTQGJRRX-JYRVWZFOSA-N

InChi Code: InChI=1S/C15H14N4O2/c1-8(11-3-2-6-17-11)13-10-7-9(18-15(16)21)4-5-12(10)19-14(13)20/h2-7,17H,1H3,(H,19,20)(H3,16,18,21)/b13-8-

SMILES Code: OC(NC1=CC2=C(N=C(O)/C2=C(C3=CC=CN3)/C)C=C1)=N


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information


References

1: Islam I, Brown G, Bryant J, Hrvatin P, Kochanny MJ, Phillips GB, Yuan S, Adler M, Whitlow M, Lentz D, Polokoff MA, Wu J, Shen J, Walters J, Ho E, Subramanyam B, Zhu D, Feldman RI, Arnaiz DO. Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: optimization of BX-517. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3819-25. PubMed PMID: 17544272.

2: Islam I, Bryant J, Chou YL, Kochanny MJ, Lee W, Phillips GB, Yu H, Adler M, Whitlow M, Ho E, Lentz D, Polokoff MA, Subramanyam B, Wu JM, Zhu D, Feldman RI, Arnaiz DO. Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3814-8. PubMed PMID: 17531483.