WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 530347
Description: Sephin1 is a selective inhibitor of a holophosphatase. Sephin1 safely and selectively inhibited a regulatory subunit of protein phosphatase 1 in vivo. Sephin1 selectively bound and inhibited the stress-induced PPP1R15A, but not the related and constitutive PPP1R15B, to prolong the benefit of an adaptive phospho-signaling pathway, protecting cells from otherwise lethal protein misfolding stress. In vivo, Sephin1 safely prevented the motor, morphological, and molecular defects of two otherwise unrelated protein-misfolding diseases in mice, Charcot-Marie-Tooth 1B, and amyotrophic lateral sclerosis. Sephin1may have potential to safely prevent two protein misfolding diseases.
MedKoo Cat#: 530347
Chemical Formula: C8H9ClN4
Exact Mass: 196.0516
Molecular Weight: 196.638
Elemental Analysis: C, 48.87; H, 4.61; Cl, 18.03; N, 28.49
Synonym: Sephin1; Sephin-1; Sephin 1, icerguastatum; icerguastat
IUPAC/Chemical Name: (E)-2-(2-Chlorobenzylidene)hydrazinecarboximidamide
InChi Key: PDWJALXSRRSUHR-LFYBBSHMSA-N
InChi Code: InChI=1S/C8H9ClN4/c9-7-4-2-1-3-6(7)5-12-13-8(10)11/h1-5H,(H4,10,11,13)/b12-5+
SMILES Code: ClC1=CC=CC=C1/C=N/NC(N)=N
Appearance: Solid powder
Purity: >95% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 196.638 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Das I, Krzyzosiak A, Schneider K, Wrabetz L, D'Antonio M, Barry N,
Sigurdardottir A, Bertolotti A. Preventing proteostasis diseases by selective
inhibition of a phosphatase regulatory subunit. Science. 2015 Apr
10;348(6231):239-42. doi: 10.1126/science.aaa4484. PubMed PMID: 25859045; PubMed
Central PMCID: PMC4490275.