Sephin1
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530347

CAS#: 951441-04-6

Description: Sephin1 is a selective inhibitor of a holophosphatase. Sephin1 safely and selectively inhibited a regulatory subunit of protein phosphatase 1 in vivo. Sephin1 selectively bound and inhibited the stress-induced PPP1R15A, but not the related and constitutive PPP1R15B, to prolong the benefit of an adaptive phospho-signaling pathway, protecting cells from otherwise lethal protein misfolding stress. In vivo, Sephin1 safely prevented the motor, morphological, and molecular defects of two otherwise unrelated protein-misfolding diseases in mice, Charcot-Marie-Tooth 1B, and amyotrophic lateral sclerosis. Sephin1may have potential to safely prevent two protein misfolding diseases.


Chemical Structure

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Sephin1
CAS# 951441-04-6

Theoretical Analysis

MedKoo Cat#: 530347
Name: Sephin1
CAS#: 951441-04-6
Chemical Formula: C8H9ClN4
Exact Mass: 196.0516
Molecular Weight: 196.638
Elemental Analysis: C, 48.87; H, 4.61; Cl, 18.03; N, 28.49

Price and Availability

Size Price Availability Quantity
50.0mg USD 450.0 2 Weeks
100.0mg USD 750.0 2 Weeks
200.0mg USD 1150.0 2 Weeks
500.0mg USD 1950.0 2 Weeks
1.0g USD 2950.0 2 Weeks
2.0g USD 5250.0 2 Weeks
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Synonym: Sephin1; Sephin-1; Sephin 1, icerguastatum; icerguastat

IUPAC/Chemical Name: (E)-2-(2-Chlorobenzylidene)hydrazinecarboximidamide

InChi Key: PDWJALXSRRSUHR-LFYBBSHMSA-N

InChi Code: InChI=1S/C8H9ClN4/c9-7-4-2-1-3-6(7)5-12-13-8(10)11/h1-5H,(H4,10,11,13)/b12-5+

SMILES Code: ClC1=CC=CC=C1/C=N/NC(N)=N

Appearance: Solid powder

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 196.638 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Das I, Krzyzosiak A, Schneider K, Wrabetz L, D'Antonio M, Barry N,
Sigurdardottir A, Bertolotti A. Preventing proteostasis diseases by selective
inhibition of a phosphatase regulatory subunit. Science. 2015 Apr
10;348(6231):239-42. doi: 10.1126/science.aaa4484. PubMed PMID: 25859045; PubMed
Central PMCID: PMC4490275.

Sephin1

50.0mg / USD 450.0