AC-55541
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530338

CAS#: 916170-19-9

Description: AC-55541 is a protease-activated receptor (PAR) 2 agonist. AC-55541activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 200 to 1000 nM. AC-55541 was well absorbed when administered intraperitoneally to rats, each reaching micromolar peak plasma concentrations. AC-55541 was stable to metabolism by liver microsomes and maintained sustained exposure in rats, with elimination half-lives of 6.1. Systemic administration of either AC-55541 or AC-264613 produced a similar degree of hyperalgesia as was observed when the compounds were administered locally. AC-55541 may be useful in probing the physiological functions of PAR2 receptors.


Chemical Structure

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AC-55541
CAS# 916170-19-9

Theoretical Analysis

MedKoo Cat#: 530338
Name: AC-55541
CAS#: 916170-19-9
Chemical Formula: C25H20BrN5O3
Exact Mass: 517.075
Molecular Weight: 518.371
Elemental Analysis: C, 57.93; H, 3.89; Br, 15.41; N, 13.51; O, 9.26

Price and Availability

Size Price Availability Quantity
10.0mg USD 90.0 2 Weeks
25.0mg USD 150.0 2 Weeks
50.0mg USD 250.0 2 Weeks
100.0mg USD 450.0 2 Weeks
200.0mg USD 650.0 2 Weeks
500.0mg USD 1350.0 2 Weeks
1.0g USD 2450.0 2 Weeks
2.0g USD 3850.0 2 Weeks
5.0g USD 4750.0 2 Weeks
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Synonym: AC-55541; AC 55541; AC55541.

IUPAC/Chemical Name: (E)-N-(2-(2-(1-(3-bromophenyl)ethylidene)hydrazinyl)-2-oxo-1-(4-oxo-3,4-dihydrophthalazin-1-yl)ethyl)benzamide

InChi Key: UCUHFWIFSHROPY-RWPZCVJISA-N

InChi Code: InChI=1S/C25H20BrN5O3/c1-15(17-10-7-11-18(26)14-17)28-31-25(34)22(27-23(32)16-8-3-2-4-9-16)21-19-12-5-6-13-20(19)24(33)30-29-21/h2-14,22H,1H3,(H,27,32)(H,30,33)(H,31,34)/b28-15+

SMILES Code: O=C1C2=CC=CC=C2C(C(NC(C3=CC=CC=C3)=O)C(N/N=C(C)/C4=CC=CC(Br)=C4)=O)=NN1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 518.371 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Homma T, Kato A, Bhushan B, Norton JE, Suh LA, Carter RG, Gupta DS, Schleimer
RP. Role of Aspergillus fumigatus in Triggering Protease-Activated Receptor-2 in
Airway Epithelial Cells and Skewing the Cells toward a T-helper 2 Bias. Am J
Respir Cell Mol Biol. 2016 Jan;54(1):60-70. doi: 10.1165/rcmb.2015-0062OC. PubMed
PMID: 26072921; PubMed Central PMCID: PMC4742929.

2: Ma JN, Burstein ES. The protease activated receptor 2 (PAR2) polymorphic
variant F240S constitutively activates PAR2 receptors and potentiates responses
to small-molecule PAR2 agonists. J Pharmacol Exp Ther. 2013 Dec;347(3):697-704.
doi: 10.1124/jpet.113.208744. PubMed PMID: 24078870.

3: Gardell LR, Ma JN, Seitzberg JG, Knapp AE, Schiffer HH, Tabatabaei A, Davis
CN, Owens M, Clemons B, Wong KK, Lund B, Nash NR, Gao Y, Lameh J, Schmelzer K,
Olsson R, Burstein ES. Identification and characterization of novel
small-molecule protease-activated receptor 2 agonists. J Pharmacol Exp Ther. 2008
Dec;327(3):799-808. doi: 10.1124/jpet.108.142570. PubMed PMID: 18768780.