VU0652925

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MedKoo CAT#: 530334

CAS#: 1476847-58-1

Description: VU0652925 is a PAR4 antagonist. VU0652925 had a PAC1 IC50 of 43.0 pM (-pIC50±SEM: 10.4±0.04) and a P-sel IC50 of 39.2 pM (-pIC50±SEM: 10.41±0.04). PAR4 antagonists is potential useful for the development of tools such as radioligands and PET tracers that are not currently available to the field for this target.


Price and Availability

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Pricing updated 2020-10-26. Prices are subject to change without notice.

VU0652925 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530334
Name: VU0652925
CAS#: 1476847-58-1
Chemical Formula: C24H18N4O4S2
Exact Mass: 490.0769
Molecular Weight: 490.552
Elemental Analysis: C, 58.76; H, 3.70; N, 11.42; O, 13.05; S, 13.07


Synonym: VU0652925, VU-0652925, VU 0652925, BMS-3, BMS 3, BMS3

IUPAC/Chemical Name: 2-methoxy-6-(6-methoxy-4-((2-phenylthiazol-4-yl)methoxy)benzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole

InChi Key: RROGCGMHOWNSLD-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H18N4O4S2/c1-29-16-8-19(31-12-15-13-33-22(25-15)14-6-4-3-5-7-14)17-10-21(32-20(17)9-16)18-11-28-23(26-18)34-24(27-28)30-2/h3-11,13H,12H2,1-2H3

SMILES Code: COC1=NN2C(S1)=NC(C3=CC4=C(O3)C=C(OC)C=C4OCC5=CSC(C6=CC=CC=C6)=N5)=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1. MOL #106666; Contributions of PAR1 and PAR4 to thrombin induced GPIIbIIIa activation in human platelets; Matthew T. Duvernay, Kayla J. Temple, Jae G. Maeng, Anna L. Blobaum, Shaun R. Stauffer, Craig W. Lindsley, Heidi E. Hamm Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232-6600, USA MTD, KJT, JGM, ALB, SRS, HEH, CWL; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA KJT, ALB, SRS, CWL; Department of Chemistry, Vanderbilt University, Nashville, TN 37232, USA SRS, CWJ Molecular Pharmacology Fast Forward. Published on October 26, 2016 as DOI: 10.1124/mol.116.106666

2. Preparation of protease activated receptor 4 (PAR4) agonist peptides and their use as PAR4 receptor activation for measuring the activity of PAR4 antagonist imidazothiadiazole and imidazopyridazine derivatives and analogs; Kornacker, Michael G.; Mapelli, Claudio; Riexinger, Douglas James
Assignee Bristol-Myers Squibb Company, USA; 2013; Patent Information; Oct 31, 2013; WO 2013163248 A1