M2I-1
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MedKoo CAT#: 406954

CAS#: 312271-03-7

Description: M2I-1, also known as Mad2 Inhibitor-1, is Protein-Protein Interaction Inhibitor Targeting the Mitotic Spindle Assembly Checkpoint. M2I-1 disturbs conformational dynamics of Mad2 critical for complex formation with Cdc20. Cellular studies revealed that M2I-1 weakens the SAC response, indicating that the compound might be active in cells.


Price and Availability

Size Price Shipping out time Quantity
100mg USD 650 2 Weeks
200mg USD 1050 2 Weeks
500mg USD 1950 2 Weeks
1g USD 2950 2 Weeks
2g USD 5450 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-06-06. Prices are subject to change without notice.

M2I-1, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406954
Name: M2I-1
CAS#: 312271-03-7
Chemical Formula: C19H24N4O4S
Exact Mass: 404.1518
Molecular Weight: 404.485
Elemental Analysis: C, 56.42; H, 5.98; N, 13.85; O, 15.82; S, 7.93


Synonym: M2I-1; M2I1; M2I 1. Mad2 Inhibitor-1.

IUPAC/Chemical Name: 5-(4-(Diisobutylamino)-3-nitrobenzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

InChi Key: BWEKPQUKWLNUKX-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H24N4O4S/c1-11(2)9-22(10-12(3)4)15-6-5-13(8-16(15)23(26)27)7-14-17(24)20-19(28)21-18(14)25/h5-8,11-12H,9-10H2,1-4H3,(H2,20,21,24,25,28)

SMILES Code: O=C(/C(C(N1)=O)=C\C2=CC=C(N(CC(C)C)CC(C)C)C([N+]([O-])=O)=C2)NC1=S


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Kastl J, Braun J, Prestel A, Möller HM, Huhn T, Mayer TU. Mad2 Inhibitor-1
(M2I-1): A Small Molecule Protein-Protein Interaction Inhibitor Targeting the
Mitotic Spindle Assembly Checkpoint. ACS Chem Biol. 2015 Jul 17;10(7):1661-6.
doi: 10.1021/acschembio.5b00121. PubMed PMID: 25978000.