ELB-139

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530315

CAS#: 188116-08-7

Description: ELB-139 is a GABA A receptor agonist potentially for the treatment of anxiety and panic disorder. ELB139 increases 5-HT in the striatum and prefrontal cortex of rats: a microdialysis study.

Chemical Structure

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ELB-139
CAS# 188116-08-7
Instruction

Theoretical Analysis

MedKoo Cat#: 530315
Name: ELB-139
CAS#: 188116-08-7
Chemical Formula: C14H16ClN3O
Exact Mass: 277.10
Molecular Weight: 277.752
Elemental Analysis: C, 60.54; H, 5.81; Cl, 12.76; N, 15.13; O, 5.76

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: ELB-139; ELB 139; ELB139.

IUPAC/Chemical Name: 1-(4-chlorophenyl)-4-(piperidin-1-yl)-1,5-dihydro-2H-imidazol-2-one

InChi Key: YGXIELIREXEJQN-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H16ClN3O/c15-11-4-6-12(7-5-11)18-10-13(16-14(18)19)17-8-2-1-3-9-17/h4-7H,1-3,8-10H2

SMILES Code: O=C1N=C(N2CCCCC2)CN1C3=CC=C(Cl)C=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 277.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Landmark CJ, Johannessen SI. Modifications of antiepileptic drugs for improved tolerability and efficacy. Perspect Medicin Chem. 2008 Feb 14;2:21-39. PubMed PMID: 19787095; PubMed Central PMCID: PMC2746576.

2: Langen B, Rundfeldt C. ELB139 an agonist at the benzodiazepine binding site increases 5-HT in the striatum and prefrontal cortex of rats: a microdialysis study. Pharmacol Biochem Behav. 2007 Jan;86(1):79-85. PubMed PMID: 17257662.

3: Rabe H, Kronbach C, Rundfeldt C, Lüddens H. The novel anxiolytic ELB139 displays selectivity to recombinant GABA(A) receptors different from diazepam. Neuropharmacology. 2007 Mar;52(3):796-801. PubMed PMID: 17087982.

4: Grunwald C, Rundfeldt C, Lankau HJ, Arnold T, Höfgen N, Dost R, Egerland U, Hofmann HJ, Unverferth K. Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors. J Med Chem. 2006 Mar 23;49(6):1855-66. PubMed PMID: 16539371.

5: Whiting PJ. GABA-A receptors: a viable target for novel anxiolytics? Curr Opin Pharmacol. 2006 Feb;6(1):24-9. Review. PubMed PMID: 16359919.

6: Shah S, Tear S. Targeting neurological receptors. IDrugs. 2005 Dec;8(12):962-3. PubMed PMID: 16320121.

7: Atack JR. The benzodiazepine binding site of GABA(A) receptors as a target for the development of novel anxiolytics. Expert Opin Investig Drugs. 2005 May;14(5):601-18. Review. PubMed PMID: 15926867.

8: Langen B, Egerland U, Bernöster K, Dost R, Unverferth K, Rundfeldt C. Characterization in rats of the anxiolytic potential of ELB139 [1-(4-chlorophenyl)-4-piperidin-1-yl-1,5-dihydro-imidazol-2-on], a new agonist at the benzodiazepine binding site of the GABAA receptor. J Pharmacol Exp Ther. 2005 Aug;314(2):717-24. PubMed PMID: 15860576.