PF-06650833
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530304

CAS#: 1817626-54-2

Description: PF-06650833, also known as Zimlovisertib, is an inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4). RAK4 is located proximal to TLR/IL-1 receptors, and in preclinical studies, inhibits downstream signaling from these receptors. The development of novel small molecule inhibitors of this kinase has the potential to lead to new therapeutics to treat diseases such as rheumatoid arthritis, lupus, and lymphomas.

Chemical Structure

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PF-06650833
CAS# 1817626-54-2
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 530304
Name: PF-06650833
CAS#: 1817626-54-2
Chemical Formula: C18H20FN3O4
Exact Mass: 361.14
Molecular Weight: 361.373
Elemental Analysis: C, 59.83; H, 5.58; F, 5.26; N, 11.63; O, 17.71

Price and Availability

Size Price Availability Quantity
50mg USD 550 2 Weeks
100mg USD 950 2 Weeks
200mg USD 1650 2 Weeks
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Synonym: PF-06650833; PF 06650833; PF06650833; PF-6650833; PF 6650833; PF6650833, Zimlovisertib

IUPAC/Chemical Name: 1-[[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxo-2-pyrrolidinyl]methoxy]-7-methoxy-6-isoquinolinecarboxamide

InChi Key: JKDGKIBAOAFRPJ-ZBINZKHDSA-N

InChi Code: InChI=1S/C18H20FN3O4/c1-3-10-13(22-17(24)15(10)19)8-26-18-11-7-14(25-2)12(16(20)23)6-9(11)4-5-21-18/h4-7,10,13,15H,3,8H2,1-2H3,(H2,20,23)(H,22,24)/t10-,13+,15-/m0/s1

SMILES Code: O=C(C1=CC2=C(C(OC[C@H]([C@H](CC)[C@@H]3F)NC3=O)=NC=C2)C=C1OC)N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target: Zimlovisertib (PF-06650833) is a potent, selective and orally active inhibitor of interleukin-1 receptor associated kinase 4 (IRAK4) with IC50s of 0.2 and 2.4 nM in the cell and PBMC assay.
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 56.9 157.40
Ethanol 3.0 8.30

Preparing Stock Solutions

The following data is based on the product molecular weight 361.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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1: Seganish WM. Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4):
a patent review (2012-2015). Expert Opin Ther Pat. 2016 Aug;26(8):917-32. doi:
10.1080/13543776.2016.1202926. PubMed PMID: 27310003.