WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 328067

CAS#: Unknown

Description: Urolinin is a linear peptidic Urotensin-II Receptor Agonist. Urolinin shows low nanomolar potency as well as improved metabolic stability. Urolinin is a hexameric UIIR agonist with an EC50 of 4.75 nM and a metabolic stability of 1319 min, 6.3-fold higher than wild-type U-II. The U-II system exhibits a remarkable potential for the development of novel therapeutic strategies, especially those related to the treatment of cardiovascular diseases.

Chemical Structure

CAS# Unknown

Theoretical Analysis

MedKoo Cat#: 328067
Name: Urolinin
CAS#: Unknown
Chemical Formula: C45H55N11O11
Exact Mass: 925.41
Molecular Weight: 926.001
Elemental Analysis: C, 58.37; H, 5.99; N, 16.64; O, 19.01

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Synonym: Urolinin; nWWK-Tyr(3-NO2)-Abu

IUPAC/Chemical Name: (2S,5S,8S,11S,14S,17R)-11,14-bis((1H-indol-3-yl)methyl)-17,19-diamino-8-(4-aminobutyl)-2-ethyl-5-(4-hydroxy-3-nitrobenzyl)-4,7,10,13,16,19-hexaoxo-3,6,9,12,15-pentaazanonadecanoic acid


InChi Code: InChI=1S/C45H55N11O11/c1-2-30(45(64)65)51-42(61)34(17-24-14-15-38(57)37(18-24)56(66)67)54-41(60)33(13-7-8-16-46)52-43(62)36(20-26-23-50-32-12-6-4-10-28(26)32)55-44(63)35(53-40(59)29(47)21-39(48)58)19-25-22-49-31-11-5-3-9-27(25)31/h3-6,9-12,14-15,18,22-23,29-30,33-36,49-50,57H,2,7-8,13,16-17,19-21,46-47H2,1H3,(H2,48,58)(H,51,61)(H,52,62)(H,53,59)(H,54,60)(H,55,63)(H,64,65)/t29-,30+,33+,34+,35+,36+/m1/s1

SMILES Code: N[C@H](CC(N)=O)C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@@H](CC3=CNC4=C3C=CC=C4)C(N[C@@H](CCCCN)C(N[C@@H](CC5=CC([N+]([O-])=O)=C(O)C=C5)C(N[C@@H](CC)C(O)=O)=O)=O)=O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:

Preparing Stock Solutions

The following data is based on the product molecular weight 926.001000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Urolinin: The First Linear Peptidic Urotensin-II Receptor Agonist Sebastian Bandholtz, Sarah Erdmann, Jan Lennart von Hacht, Samantha Exner, Gerd Krause, Gunnar Kleinau, and Carsten Grötzinger Publication Date (Web): October 28, 2016 (Article) DOI: 10.1021/acs.jmedchem.6b00164