WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 329409

CAS#: 89796-99-6

Description: Aceclofenac, also known as Airtal and YT-919, is a cyclooxygenase-2 inhibitor used to treat osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. Aceclofenac has improved gastrointestinal tolerance compared with other nonsteroidal anti-inflammatory drugs.

Chemical Structure

CAS# 89796-99-6

Theoretical Analysis

MedKoo Cat#: 329409
Name: Aceclofenac
CAS#: 89796-99-6
Chemical Formula: C16H13Cl2NO4
Exact Mass: 353.0222
Molecular Weight: 354.183
Elemental Analysis: C, 54.26; H, 3.70; Cl, 20.02; N, 3.95; O, 18.07

Price and Availability

Size Price Availability Quantity
1.0g USD 205.0 2 Weeks
5.0g USD 350.0 2 Weeks
10.0g USD 550.0 2 Weeks
25.0g USD 1000.0 2 Weeks
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Synonym: Aceclofenac; YT-919; YT 919; YT919; Airtal; Beofenac

IUPAC/Chemical Name: 2-(2-(2-((2,6-dichlorophenyl)amino)phenyl)acetoxy)acetic acid


InChi Code: InChI=1S/C16H13Cl2NO4/c17-11-5-3-6-12(18)16(11)19-13-7-2-1-4-10(13)8-15(22)23-9-14(20)21/h1-7,19H,8-9H2,(H,20,21)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 354.183 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Ganesh M, Jeon UJ, Ubaidulla U, Hemalatha P, Saravanakumar A, Peng MM, Jang HT. Chitosan cocrystals embedded alginate beads for enhancing the solubility and bioavailability of aceclofenac. Int J Biol Macromol. 2015 Mar;74:310-7. doi: 10.1016/j.ijbiomac.2014.12.038. PubMed PMID: 25557368.

2: Raju YP, Haritha K, Satyanarayana RP, Vandana KR, Bindu DT, Vinesha V, Chowdary VH. Formulation and Characterization of Aceclofenac -Aloe vera Transemulgel. Curr Drug Deliv. 2015;12(6):703-8. PubMed PMID: 25751659.

3: Noh K, Shin BS, Kwon KI, Yun HY, Kim E, Jeong TC, Kang W. Absolute bioavailability and metabolism of aceclofenac in rats. Arch Pharm Res. 2015 Jan;38(1):68-72. doi: 10.1007/s12272-014-0350-4. PubMed PMID: 24633464.

4: Koly SF, Kundu SP, Kabir S, Amran MS, Sultan MZ. Analysis of aceclofenac and bovine serum albumin interaction using fluorescence quenching method for predictive, preventive, and personalized medicine. EPMA J. 2015 Dec 14;6:24. doi: 10.1186/s13167-015-0047-x. PubMed PMID: 26668672; PubMed Central PMCID: PMC4677438.

5: Galligan TH, Taggart MA, Cuthbert RJ, Svobodova D, Chipangura J, Alderson D, Prakash VM, Naidoo V. Metabolism of aceclofenac in cattle to vulture-killing diclofenac. Conserv Biol. 2016 Oct;30(5):1122-7. doi: 10.1111/cobi.12711. PubMed PMID: 26931376.

6: Kim MJ, Lim HS, Noh YH, Kim YH, Choi HY, Park KM, Kim SE, Bae KS. Pharmacokinetic interactions between eperisone hydrochloride and aceclofenac: a randomized, open-label, crossover study of healthy Korean men. Clin Ther. 2013 Oct;35(10):1528-35. doi: 10.1016/j.clinthera.2013.08.012. PubMed PMID: 24050970.

7: Lee TY, Choi JS, Oh HC, Song TJ, Do JH, Cheon YK. Oral udenafil and aceclofenac for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis in high-risk patients: a randomized multicenter study. Korean J Intern Med. 2015 Sep;30(5):602-9. doi: 10.3904/kjim.2015.30.5.602. PubMed PMID: 26354054; PubMed Central PMCID: PMC4578023.

8: Jana S, Samanta A, Nayak AK, Sen KK, Jana S. Novel alginate hydrogel core-shell systems for combination delivery of ranitidine HCl and aceclofenac. Int J Biol Macromol. 2015 Mar;74:85-92. doi: 10.1016/j.ijbiomac.2014.11.027. PubMed PMID: 25478963.

9: Pareek A, Chandurkar N. Comparison of gastrointestinal safety and tolerability of aceclofenac with diclofenac: a multicenter, randomized, double-blind study in patients with knee osteoarthritis. Curr Med Res Opin. 2013 Jul;29(7):849-59. doi: 10.1185/03007995.2013.795139. PubMed PMID: 23581533.

10: Kumar D, Sailaja Chirravuri SV, Shastri NR. Impact of surface area of silica particles on dissolution rate and oral bioavailability of poorly water soluble drugs: a case study with aceclofenac. Int J Pharm. 2014 Jan 30;461(1-2):459-68. doi: 10.1016/j.ijpharm.2013.12.017. PubMed PMID: 24368106.

11: Moon YW, Kang SB, Kim TK, Lee MC. Efficacy and Safety of Aceclofenac Controlled Release in Patients with Knee Osteoarthritis: A 4-week, Multicenter, Randomized, Comparative Clinical Study. Knee Surg Relat Res. 2014 Mar;26(1):33-42. doi: 10.5792/ksrr.2014.26.1.33. PubMed PMID: 24639945; PubMed Central PMCID: PMC3953523.

12: Medhi B, Joshi R, Prakash A, Bansal YS, Attrey SD, Singh D, Pandhi P. Effect of aceclofenac on pharmacokinetic of phenytoin. Pak J Pharm Sci. 2012 Apr;25(2):295-9. PubMed PMID: 22459452.

13: Kale MA, Shelke R, Nawale RB. Zinc-aceclofenac complex: synthesis, hydrolysis study and antiinflammatory studies. Antiinflamm Antiallergy Agents Med Chem. 2014 Mar;13(1):36-44. PubMed PMID: 24484209.

14: Bae SK, Kim SH, Lee HW, Seong SJ, Shin SY, Lee SH, Lim MS, Yoon YR, Lee HJ. Pharmacokinetics of a new once-daily controlled-release formulation of aceclofenac in Korean healthy subjects compared with immediate-release aceclofenac and the effect of food: a randomized, open-label, three-period, crossover, single-centre study. Clin Drug Investig. 2012 Feb 1;32(2):111-9. doi: 10.2165/11596530-000000000-00000. PubMed PMID: 22149151.

15: Jana S, Manna S, Nayak AK, Sen KK, Basu SK. Carbopol gel containing chitosan-egg albumin nanoparticles for transdermal aceclofenac delivery. Colloids Surf B Biointerfaces. 2014 Feb 1;114:36-44. doi: 10.1016/j.colsurfb.2013.09.045. PubMed PMID: 24161504.