Ro 24-7429

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526182

CAS#: 139339-45-0

Description: Ro 24-7429 is a Tat antagonist. Ro 24-7429 blocks the action of the HIV tat protein and is an analog of Ro 5-3335.

Chemical Structure

Ro 24-7429
CAS# 139339-45-0

Theoretical Analysis

MedKoo Cat#: 526182
Name: Ro 24-7429
CAS#: 139339-45-0
Chemical Formula: C14H13ClN4
Exact Mass: 272.0829
Molecular Weight: 272.74
Elemental Analysis: C, 61.65; H, 4.80; Cl, 13.00; N, 20.54

Price and Availability

Size Price Availability Quantity
5.0mg USD 190.0 Ready to ship
10.0mg USD 350.0 Ready to ship
25.0mg USD 650.0 Ready to ship
50.0mg USD 1150.0 Ready to ship
100.0mg USD 1850.0 Ready to ship
200.0mg USD 2950.0 Ready to ship
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Related CAS #: 139339-45-0   2328140-37-8   30195-30-3    

Synonym: Ro 24-7429; Ro-24-7429; Ro247429; Ro247429; Ro-247429; Ro 247429;

IUPAC/Chemical Name: 3H-1,4-Benzodiazepin-2-amine, 7-chloro-N-methyl-5-(1H-pyrrol-2-yl)-


InChi Code: InChI=1S/C14H13ClN4/c1-16-13-8-18-14(12-3-2-6-17-12)10-7-9(15)4-5-11(10)19-13/h2-7,17H,8H2,1H3,(H,16,19)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 272.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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O'Hare M, Amarnani D, Whitmore HAB, An M, Marino C, Ramos L, Delgado-Tirado S, Hu X, Chmielewska N, Chandrahas A, Fitzek A, Heinrich F, Steurer S, Ondruschka B, Glatzel M, Krasemann S, Sepulveda-Falla D, Lagares D, Pedron J, Bushweller JH, Liu P, Arboleda-Velasquez JF, Kim LA. Targeting RUNX1 prevents pulmonary fibrosis and reduces expression of SARS-CoV-2 host mediators. Am J Pathol. 2021 Apr 21:S0002-9440(21)00161-9. doi: 10.1016/j.ajpath.2021.04.006. Epub ahead of print. PMID: 33894177; PMCID: PMC8059259.

1: Patki AH, Lederman MM. HIV-1 Tat protein and its inhibitor Ro 24-7429 inhibit lymphocyte proliferation and induce apoptosis in peripheral blood mononuclear cells from healthy donors. Cell Immunol. 1996 Apr 10;169(1):40-6. PubMed PMID:8612292.

2: Haubrich RH, Flexner C, Lederman MM, Hirsch M, Pettinelli CP, Ginsberg R, Lietman P, Hamzeh FM, Spector SA, Richman DD. A randomized trial of the activity and safety of Ro 24-7429 (Tat antagonist) versus nucleoside for human immunodeficiency virus infection. The AIDS Clinical Trials Group 213 Team. J Infect Dis. 1995 Nov;172(5):1246-52. PubMed PMID: 7594660.

3: Dunne AL, Siregar H, Mills J, Crowe SM. HIV replication in chronically infected macrophages is not inhibited by the Tat inhibitors Ro-5-3335 and Ro-24-7429. J Leukoc Biol. 1994 Sep;56(3):369-73. PubMed PMID: 8083610.