Azeloprazole

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526902

CAS#: 955095-45-1 (free)

Description: Azeloprazole, also known as E-3710 and Z-215, is a proton pump inhibitor potentially for treatment of gastroesophageal reflux disease (GERD).


Price and Availability

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Azeloprazole (E-3710) is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526902
Name: Azeloprazole
CAS#: 955095-45-1 (free)
Chemical Formula: C22H27N3O4S
Exact Mass: 429.1722
Molecular Weight: 429.535
Elemental Analysis: C, 61.52; H, 6.34; N, 9.78; O, 14.90; S, 7.46


Synonym: E-3710; E 3710; E3710; Z-215; Z 215; Z215; Azeloprazole

IUPAC/Chemical Name: (R)-2-(((4-((2,2-Dimethyl-1,3-dioxan-5-yl)methoxy)-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole

InChi Key: DWDKHTXMLSZGDL-SSEXGKCCSA-N

InChi Code: InChI=1S/C22H27N3O4S/c1-14-9-23-19(13-30(26)21-24-17-7-5-6-8-18(17)25-21)15(2)20(14)27-10-16-11-28-22(3,4)29-12-16/h5-9,16H,10-13H2,1-4H3,(H,24,25)/t30-/m1/s1

SMILES Code: O=[S@@](C1=NC2=CC=CC=C2N1)CC3=NC=C(C)C(OCC4COC(C)(C)OC4)=C3C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

Related CAS#
955095-45-1 (E-3710 free)
955095-47-3 (E-3710 sodium salt)


References

1: Kodama K, Fujisaki H, Kubota A, Kato H, Hirota K, Kuramochi H, Murota M,
Tabata Y, Ueda M, Harada H, Kawahara T, Shinoda M, Watanabe N, Iida D, Terauchi
H, Yasui S, Miyazawa S, Nagakawa J. E3710, a new proton pump inhibitor, with a
long-lasting inhibitory effect on gastric acid secretion. J Pharmacol Exp Ther.
2010 Aug;334(2):395-401. doi: 10.1124/jpet.110.167783. Epub 2010 May 19. PubMed
PMID: 20484556.