AZD7986
featured

Orders received during 11/25~11/29 will be shipped in 11/30/2020 due to Thanksgiving holiday.

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526881

CAS#: 1802148-05-5

Description: Brensocatib, also known as AZD7986, INS 1007, is a second generation reversible covalent, potent and selective DPP1 inhibitor which may be used in the treatment of chronic obstructive pulmonary disease (COPD). AZD7986 is also a Cathepsin C inhibitor.


Price and Availability

Size Price Shipping out time Quantity
5mg USD 90 Same day
10mg USD 150 Same day
25mg USD 250 Same day
50mg USD 450 Same day
100mg USD 850 Same day
200mg USD 1450 Same day
500mg USD 2250 Same day
1g USD 3250 2 Weeks
2g USD 5850 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-11-29. Prices are subject to change without notice.

AZD7986, purity > 98%, is in stock. The same day shipping after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 526881
Name: AZD7986
CAS#: 1802148-05-5
Chemical Formula: C23H24N4O4
Exact Mass: 420.1798
Molecular Weight: 420.469
Elemental Analysis: C, 65.70; H, 5.75; N, 13.33; O, 15.22


Synonym: AZD7986; AZD-7986; AZD 7986; INS 1007; INS-1007; INS1007, Brensocatib

IUPAC/Chemical Name: (S)-N-((S)-1-cyano-2-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)ethyl)-1,4-oxazepane-2-carboxamide

InChi Key: AEXFXNFMSAAELR-RXVVDRJESA-N

InChi Code: InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1

SMILES Code: N#C[C@H](CC1=CC=C(C2=CC=C(OC(N3C)=O)C3=C2)C=C1)NC([C@H]4OCCCNC4)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Doyle K, Lönn H, Käck H, Van de Poël A, Swallow S, Gardiner P, Connolly S,
Root J, Wikell C, Dahl G, Stenvall K, Johannesson P. Discovery of Second
Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane
Amidoacetonitrile Based Clinical Candidate (AZD7986). J Med Chem. 2016 Oct 2.
PubMed PMID: 27690432.