Propanidid
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526058

CAS#: 1421-14-3

Description: Propanidid, also known as Sombrevin, is a short-acting phenylacetate general anesthetic.


Chemical Structure

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Propanidid
CAS# 1421-14-3

Theoretical Analysis

MedKoo Cat#: 526058
Name: Propanidid
CAS#: 1421-14-3
Chemical Formula: C18H27NO5
Exact Mass: 337.19
Molecular Weight: 337.420
Elemental Analysis: C, 64.07; H, 8.07; N, 4.15; O, 23.71

Price and Availability

Size Price Availability Quantity
100mg USD 450
200mg USD 650
500mg USD 950
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Synonym: Propanidid; Epontol; Fabantol; Fabontal; FBA 1420; BAY-1420, Sombrevin; TH-2180; WH 5668.

IUPAC/Chemical Name: propyl 2-(4-(2-(diethylamino)-2-oxoethoxy)-3-methoxyphenyl)acetate

InChi Key: KEJXLQUPYHWCNM-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H27NO5/c1-5-10-23-18(21)12-14-8-9-15(16(11-14)22-4)24-13-17(20)19(6-2)7-3/h8-9,11H,5-7,10,12-13H2,1-4H3

SMILES Code: O=C(OCCC)CC1=CC=C(OCC(N(CC)CC)=O)C(OC)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 337.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Ball C, Westhorpe R. Intravenous Induction Agents--propanidid. Anaesth Intensive Care. 2002 Jun;30(3):261. PubMed PMID: 12075631.

2: Klockgether-Radke A, Kersten J, Schröder T, Stafforst D, Kettler D, Hellige G. [Anesthesia with propanidid in a liposomal preparation. An experimental study in swine]. Anaesthesist. 1995 Aug;44(8):573-80. German. PubMed PMID: 7573906.

3: Sütterlin R. [Comments on the paper by H. Habazettl et al. The anesthetic usefulness of propanidid as a liposome dispersion]. Anaesthesist. 1994 Jan;43(1):50-2. German. PubMed PMID: 8122725.

4: Habazettl H, Vollmar B, Röhrich F, Conzen P, Doenicke A, Baethmann A. [Anesthesiologic efficacy of propanidid as a liposome dispersion. An experimental study with rats]. Anaesthesist. 1992 Aug;41(8):448-56. German. PubMed PMID: 1524155.

5: Zawisza P, Przyborowski L. [Propanidid and etomidate identification from the blood by thin-layer chromatography]. Acta Pol Pharm. 1992;49(5-6):15-7. Polish. PubMed PMID: 16092193.

6: Zawisza P, Przyborowski L. [High-performance liquid chromatographic determination of propanidid and etomidate]. Acta Pol Pharm. 1992;49(5-6):11-3. Polish. PubMed PMID: 16092192.

7: Rzymski S, Szyszka A, Wachowiak H, Kaczmarek J, Mrozikiewicz A. [Comparative evaluation of anesthesia with etomidate and propanidid in patients undergoing electric cardioversion]. Pol Tyg Lek. 1991 Aug 5-19;46(32-34):592-4. Polish. PubMed PMID: 1669119.

8: Toque Y, Fortaine MR, Delloue M, Lephay A, Khoury A, Ossart M. [Intravenous anesthesia for cesarean section. Comparison of propanidid and methohexital]. Agressologie. 1991;32(4):246-9. French. PubMed PMID: 1957966.

9: Deschodt J, Lubrano JF, Peschaud JL, Eledjam JJ, du Cailar J. [Comparison of propofol and propanidid administered at a constant rate]. Ann Fr Anesth Reanim. 1988;7(6):459-63. French. PubMed PMID: 3066240.

10: Ennis M, Lorenz W, Gerland W, Heise J. Isolation of mast cells from rabbit lung and liver: comparison of histamine release induced by the hypnotics Althesin and propanidid. Agents Actions. 1987 Apr;20(3-4):219-22. PubMed PMID: 2440276.

11: Bertrand D, Taron F, Manel J, Laxenaire MC. [Propofol versus propanidid for the conduction of suspension laryngoscopy]. Ann Fr Anesth Reanim. 1987;6(4):289-92. French. PubMed PMID: 3498402.

12: Marcillon M, Mérot S, Rives E, Ghariani M, Gard JO, Raucoules M, Maestracci P. [Comparison of propanidid with propofol for dental surgery of short or medium duration]. Ann Fr Anesth Reanim. 1987;6(4):285-8. French. PubMed PMID: 3307548.

13: Kirkness EF, Turner AJ. The gamma-aminobutyrate/benzodiazepine receptor from pig brain. Enhancement of gamma-aminobutyrate-receptor binding by the anaesthetic propanidid. Biochem J. 1986 Jan 1;233(1):259-64. PubMed PMID: 3006660; PubMed Central PMCID: PMC1153013.

14: González de Zárate Apiñaniz J, García Domínguez R, Rodríguez Abela J, Baeza Gil C, Girón Montáñez R. [Rheologic effects of propanidid-cremophor EL]. Rev Esp Anestesiol Reanim. 1985 Nov-Dec;32(6):264-6. Spanish. PubMed PMID: 4089278.

15: Guerrero J, Trevilla JM, de las Mulas M, Herrera JC, Malagón F. [Anaphylactic reaction to propanidid]. Rev Esp Anestesiol Reanim. 1985 Sep-Oct;32(5):252-3. Spanish. PubMed PMID: 2417288.

16: Nousiainen U. Effects of phenobarbital and p,p'-DDT on carboxylesterase activity and hydrolysis of propanidid in rat liver. Gen Pharmacol. 1985;16(1):49-53. PubMed PMID: 3979796.

17: Nousiainen U, Raatikainen O. High-performance liquid chromatography of propanidid in rat plasma. J Chromatogr. 1984 Jun 8;308:376-81. PubMed PMID: 6746830.

18: Christmas D. Immune reaction to propanidid. Anaesthesia. 1984 May;39(5):470-3. PubMed PMID: 6731777.

19: Nousiainen U. The effects of phenobarbital, bis-p-nitrophenyl phosphate and disulfiram on the hydrolysis of propanidid in Wistar rats. Gen Pharmacol. 1984;15(5):397-402. PubMed PMID: 6510675.

20: Bertoletti PL, Ciucci N, Gavinelli R, Vignolo Lutati C, Cigna P, Jacob RM. [Control of immediate and long-term effects on the fetus and the newborn infant after labor analgesia with propanidid]. Minerva Ginecol. 1983 Nov;35(11):739-45. Italian. PubMed PMID: 6669313.