Halothane
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MedKoo CAT#: 328805

CAS#: 151-67-7

Description: Halothane, also known as Fluothane, is a CYP3A4 substrate used for anesthesia.

Chemical Structure

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Halothane
CAS# 151-67-7
Instruction

Theoretical Analysis

MedKoo Cat#: 328805
Name: Halothane
CAS#: 151-67-7
Chemical Formula: C2HBrClF3
Exact Mass: 195.89
Molecular Weight: 197.379
Elemental Analysis: C, 12.17; H, 0.51; Br, 40.48; Cl, 17.96; F, 28.88

Price and Availability

Size Price Availability Quantity
125mL USD 400 2 Weeks
250mL USD 700 2 Weeks
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Synonym: Halothane; Fluothane; BRN 1736947; BRN-1736947; BRN1736947;

IUPAC/Chemical Name: 2-bromo-2-chloro-1,1,1-trifluoroethane

InChi Key: BCQZXOMGPXTTIC-UHFFFAOYSA-N

InChi Code: InChI=1S/C2HBrClF3/c3-1(4)2(5,6)7/h1H

SMILES Code: FC(F)(F)C(Br)Cl

Appearance: Liquid

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 197.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: MacDonald BA, Chakravarthy KV, Davidson BA, Mullan BA, Alluri R, Hakansson AP, Knight PR. Halothane modulates the type i interferon response to influenza and minimizes the risk of secondary bacterial pneumonia through maintenance of neutrophil recruitment in an animal model. Anesthesiology. 2015 Sep;123(3):590-602. doi: 10.1097/ALN.0000000000000766. PubMed PMID: 26120770; PubMed Central PMCID: PMC4678100.

2: Chakraborty M, Fullerton AM, Semple K, Chea LS, Proctor WR, Bourdi M, Kleiner DE, Zeng X, Ryan PM, Dagur PK, Berkson JD, Reilly TP, Pohl LR. Drug-induced allergic hepatitis develops in mice when myeloid-derived suppressor cells are depleted prior to halothane treatment. Hepatology. 2015 Aug;62(2):546-57. doi: 10.1002/hep.27764. Epub 2015 Mar 25. PubMed PMID: 25712247.

3: Li F, Liao D, Liu J, Xiao L, Guo J, Yi M, Zhou C. Emulsified halothane produces long-term epidural anesthetic effect: a study in rabbits. Int J Clin Exp Pathol. 2015 May 1;8(5):4573-80. eCollection 2015. PubMed PMID: 26191147; PubMed Central PMCID: PMC4503019.

4: Wang J, Yang X, Xiao H, Kong J, Bing M. Determination of the mechanism of action of repetitive halothane exposure on rat brain tissues using a combined method of microarray gene expression profiling and bioinformatics analysis. Mol Med Rep. 2015 Dec;12(6):8071-6. doi: 10.3892/mmr.2015.4462. Epub 2015 Oct 21. PubMed PMID: 26497548.

5: Michelucci A, Paolini C, Canato M, Wei-Lapierre L, Pietrangelo L, De Marco A, Reggiani C, Dirksen RT, Protasi F. Antioxidants protect calsequestrin-1 knockout mice from halothane- and heat-induced sudden death. Anesthesiology. 2015 Sep;123(3):603-17. doi: 10.1097/ALN.0000000000000748. PubMed PMID: 26132720; PubMed Central PMCID: PMC4543432.

6: Nomura H, Nakamura Y, Cao X, Honda A, Katagi J, Ohara H, Izumi-Nakaseko H, Satoh Y, Ando K, Sugiyama A. Cardiohemodynamic and electrophysiological effects of a selective EP4 receptor agonist ONO--AE1--329 in the halothane-anesthetized dogs. Eur J Pharmacol. 2015 Aug 15;761:217-25. doi: 10.1016/j.ejphar.2015.06.012. Epub 2015 Jun 11. PubMed PMID: 26073024.

7: Wada T, Nakamura Y, Cao X, Ohara H, Izumi-Nakaseko H, Ando K, Nakazato Y, Sugiyama A. Antiviral drug vidarabine possessing cardiac type 5 adenylyl cyclase inhibitory property did not affect cardiohemodynamic or electrophysiological variables in the halothane-anesthetized dogs. J Toxicol Sci. 2016 Feb;41(1):115-22. doi: 10.2131/jts.41.115. PubMed PMID: 26763398.

8: da Silva FF, Duflot D, Hoffmann SV, Jones NC, Rodrigues FN, Ferreira-Rodrigues AM, de Souza GG, Mason NJ, Eden S, Limão-Vieira P. Electronic State Spectroscopy of Halothane As Studied by ab Initio Calculations, Vacuum Ultraviolet Synchrotron Radiation, and Electron Scattering Methods. J Phys Chem A. 2015 Aug 6;119(31):8503-11. doi: 10.1021/acs.jpca.5b05308. Epub 2015 Jul 28. PubMed PMID: 26171941.

9: Bezerra FJ, Brown M, Alarcon W, Karki K, Knight RA, Keenan KA, Nagaraja TN. Rate and extent of leakage of a magnetic resonance contrast agent tend to be lower under isoflurane anesthesia in comparison to halothane in a rat model of embolic stroke. Neurol Res. 2014 Sep;36(9):847-50. doi: 10.1179/1743132814Y.0000000341. Epub 2014 Mar 7. PubMed PMID: 24601723.

10: Warrener T, Tindall M, Stanley D. The return of halothane anaesthesia? Eur J Anaesthesiol. 2014 Dec;31(12):709-10. doi: 10.1097/EJA.0000000000000069. PubMed PMID: 24809479.