WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 328803

CAS#: 53648-05-8

Description: Ibuproxam, also known as Ibuproxamum and G-277, is a nonsteroidal antiinflammatory drug (NSAID) used to treat musculoskeletal pain, arthritis, and soft-tissue disorders.

Chemical Structure

CAS# 53648-05-8

Theoretical Analysis

MedKoo Cat#: 328803
Name: Ibuproxam
CAS#: 53648-05-8
Chemical Formula: C13H19NO2
Exact Mass: 221.1416
Molecular Weight: 221.3
Elemental Analysis: C, 70.56; H, 8.65; N, 6.33; O, 14.46

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Ibuproxam; G-277; G-277; G-277; Ibuproxamum

IUPAC/Chemical Name: N-hydroxy-2-(4-isobutylphenyl)propanamide


InChi Code: InChI=1S/C13H19NO2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(15)14-16/h4-7,9-10,16H,8H2,1-3H3,(H,14,15)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 221.3 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Bole-Vunduk B, Verhnjak K, Zmitek J. Anti-inflammatory, analgesic and ulcerogenic properties of S-(+)-ibuproxam, racemic ibuproxam-beta-cyclodextrin and S-(+)-ibuproxam-beta-cyclodextrin. J Pharm Pharmacol. 1996 Nov;48(11):1153-7. PubMed PMID: 8961164.

2: Orzalesi G, Mari F, Bertol E, Selleri R, Pisaturo G. Anti-inflammatory agents: determination of ibuproxam and its metabolite humans. Correlation between bioavailability, tolerance and chemico-physical characteristics. Arzneimittelforschung. 1980;30(9):1607-9. PubMed PMID: 7193032.

3: Mura P, Zerrouk N, Faucci M, Maestrelli F, Chemtob C. Comparative study of ibuproxam complexation with amorphous beta-cyclodextrin derivatives in solution and in the solid state. Eur J Pharm Biopharm. 2002 Sep;54(2):181-91. PubMed PMID: 12191690.

4: Mura P, Faucci MT, Manderioli A, Bramanti G, Ceccarelli L. Compatibility study between ibuproxam and pharmaceutical excipients using differential scanning calorimetry, hot-stage microscopy and scanning electron microscopy. J Pharm Biomed Anal. 1998 Oct;18(1-2):151-63. PubMed PMID: 9863953.

5: Cirri M, Mura P, Rabasco AM, Ginés JM, Moyano JR, Gònzalez-Rodrìguez ML. Characterization of ibuproxam binary and ternary dispersions with hydrophilic carriers. Drug Dev Ind Pharm. 2004 Jan;30(1):65-74. PubMed PMID: 15000431.

6: Ferri S, Di Febo G, Biasco G, Ceroni G, Mariotti S, Muraccini F, Urbani D. [Our experience with the effectiveness and tolerance of ibuproxam in rheumatology]. Minerva Med. 1983 Feb 25;74(7):331-6. Italian. PubMed PMID: 6572296.

7: Mura P, Adragna E, Rabasco AM, Moyano JR, Pérez-Martìnez JI, Arias MJ, Ginés JM. Effects of the host cavity size and the preparation method on the physicochemical properties of ibuproxam-cyclodextrin systems. Drug Dev Ind Pharm. 1999 Mar;25(3):279-87. PubMed PMID: 10071820.

8: Chimichi S, Innocenti F, Orzalesi G. Thermal decomposition of ibuproxam. J Pharm Sci. 1980 May;69(5):521-3. PubMed PMID: 7381734.

9: Orzalesi G, Selleri R, Caldini O, Volpato I, Innocenti F, Colome J, Sacristan A, Varez G. Ibuproxam and ibuprofen. A pharmacological comparison. Arzneimittelforschung. 1977;27(5):1006-12. PubMed PMID: 577862.

10: Orzalesi G, Selleri R, Caldini O, Volpato I, Innocenti F, Colome J, Sacristan A, Varez G, Pisaturo G. Determination of ibuproxam and its metabolites in the plasma and urine of rats. Arzneimittelforschung. 1977;27(5):1012-5. PubMed PMID: 577863.