Parogrelil hydrochloride

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MedKoo CAT#: 326962

CAS#: 878796-94-2 (HCl)

Description: Parogrelil, also known as INDI-702; NM-702; NT-702, is a phosphodiesterase (PDE3/PDE5A) inhibitor potentially for the treatment of intermittent. Parogrelil improves reduced walking distance and lowered hindlimb plantar surface temperature in a rat experimental intermittent claudication model. Parogrelil suppress the asthmatic response in guinea pigs, with both bronchodilating and anti-inflammatory effects. NT-702 has an anti-inflammatory effect as well as a bronchodilating effect and might be useful as a novel potent therapeutic agent for the treatment of bronchial asthma, a new type of agent with both a bronchodilating and an anti-inflammatory effect.


Price and Availability

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Pricing updated 2020-07-12. Prices are subject to change without notice.

Parogrelil hydrochloride is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 326962
Name: Parogrelil hydrochloride
CAS#: 878796-94-2 (HCl)
Chemical Formula: C19H19BrCl2N4O2
Exact Mass:
Molecular Weight: 486.191
Elemental Analysis: C, 46.94; H, 3.94; Br, 16.43; Cl, 14.58; N, 11.52; O, 6.58


Related CAS #: 139145-27-0 (free base)   878796-94-2 (HCl)    

Synonym: Parogrelil hydrochloride; INDI-702; NM-702; NT-702; INDI702; NM702; NT702.

IUPAC/Chemical Name: 4-Bromo-6-(3-(4-chlorophenyl)propoxy)-5-(3-pyridylmethylamino)-3(2H)-pyridazinone hydrochloride

InChi Key: QWGUGDYWUADMGB-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H18BrClN4O2.ClH/c20-16-17(23-12-14-3-1-9-22-11-14)19(25-24-18(16)26)27-10-2-4-13-5-7-15(21)8-6-13;/h1,3,5-9,11H,2,4,10,12H2,(H2,23,24,26);1H

SMILES Code: O=C1C(Br)=C(NCC2=CC=CN=C2)C(OCCCC3=CC=C(Cl)C=C3)=NN1.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


Additional Information

Related CAS#
CAS#139145-27-0 (Parogrelil)
CAS#139145-84-9 (Parogrelil hydrochloride)


References

1: Zhao HP, Xiang BR. Discontinued cardiovascular drugs in 2013 and 2014. Expert
Opin Investig Drugs. 2015;24(8):1083-92. doi: 10.1517/13543784.2015.1051619.
PubMed PMID: 26162717.

2: Hori M, Iwama T, Asakura Y, Kawanishi M, Kamon J, Hoshino A, Takahashi S,
Takahashi K, Nakaike S, Tsuruzoe N. NT-702 (parogrelil hydrochloride, NM-702), a
novel and potent phosphodiesterase 3 inhibitor, suppress the asthmatic response
in guinea pigs, with both bronchodilating and anti-inflammatory effects. Eur J
Pharmacol. 2009 Sep 15;618(1-3):63-9. doi: 10.1016/j.ejphar.2009.07.005. Epub
2009 Jul 17. PubMed PMID: 19616537.

3: Ishiwata N, Noguchi K, Kawanishi M, Asakura Y, Hori M, Mitani A, Ito Y,
Takahashi K, Nishiyama H, Shudo N, Takahashi S, Takahashi K, Tsuruzoe N, Nakaike
S. NT-702 (parogrelil hydrochloride, NM-702), a novel and potent
phosphodiesterase inhibitor, improves reduced walking distance and lowered
hindlimb plantar surface temperature in a rat experimental intermittent
claudication model. Life Sci. 2007 Sep 1;81(12):970-8. Epub 2007 Aug 8. PubMed
PMID: 17850826.