Terazosin HCl hydrate | CAS#63074-08-8 | CAS#70024-40-7 | Adrenergic Receptor Antagonist

Terazosin HCl hydrate
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 328305

CAS#: 70024-40-7 (HCl)

Description: Terazosin, also known as Hytrin and A-45975, is an adrenergic receptor antagonist used to treat hypertension and benign prostatic hypertrophy.

Chemical Structure

Terazosin HCl hydrate

CAS# 70024-40-7 (HCl)

Instruction

Theoretical Analysis

MedKoo Cat#: 328305
Name: Terazosin HCl hydrate
CAS#: 70024-40-7 (HCl)
Chemical Formula: C19H30ClN5O6
Exact Mass: 387.19
Molecular Weight: 459.930
Elemental Analysis: C, 49.62; H, 6.57; Cl, 7.71; N, 15.23; O, 20.87

Price and Availability

Size	Price	Availability	Quantity
100mg	USD 350
200mg	USD 550
500mg	USD 950
1g	USD 1650
2g	USD 2150
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 63074-08-8 (free base) 70024-40-7 (HCl)

Synonym: Terazosin; Terazosin hydrochloride; Hytrin; A-45975; A 45975; A45975; Terazosin HCl hydrate; Terazosin HCl dihydrate

IUPAC/Chemical Name: (4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(tetrahydrofuran-2-yl)methanone hydrochloride dihydrate

InChi Key: NZMOFYDMGFQZLS-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H25N5O4.ClH.2H2O/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;;;/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22);1H;2*1H2

SMILES Code: O=C(N1CCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)C4OCCC4.[H]Cl.[H]O[H].[H]O[H]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Related CAS# 70024-40-7 (Terazosin hydrochloride) 63590-64-7 (Terazosin)

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 459.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Wang J, Yan D, Liang K, Xu Z. A randomized controlled trial of levofloxacin, terazosin, and combination therapy in patients with category III chronic prostatitis/chronic pelvic pain syndrome. Int Urol Nephrol. 2016 Jan;48(1):13-8. doi: 10.1007/s11255-015-1147-1. Epub 2015 Nov 17. PubMed PMID: 26577998.

2: Vidal Margenat A, Ferrando-Castagnetto F, Martínez F, Lluberas N, Vignolo G. Myocardial infarction induced by oral terazosin in a patient with predisposing structural cardiomyopathy: case report. Medwave. 2016 Jun 28;16(5):e6480. doi: 10.5867/medwave.2016.05.6480. English, Spanish. PubMed PMID: 27392141.

3: Nirmalani-Gandhy A, Sanchez D, Catalano G. Terazosin for the treatment of trauma-related nightmares: a report of 4 cases. Clin Neuropharmacol. 2015 May-Jun;38(3):109-11. doi: 10.1097/WNF.0000000000000077. PubMed PMID: 25970279.

4: Tehranchi A, Rezaei Y, Khalkhali H, Rezaei M. Effects of terazosin and tolterodine on ureteral stent related symptoms: a double-blind placebo-controlled randomized clinical trial. Int Braz J Urol. 2013 Nov-Dec;39(6):832-40. doi: 10.1590/S1677-5538.IBJU.2013.06.09. PubMed PMID: 24456787.

5: Guo X, Wu H, Guo S, Shi Y, DU J, Zhu P, DU L. Highly Sensitive Fluorescence Methods for the Determination of Alfuzosin, Doxazosin, Terazosin and Prazosin in Pharmaceutical Formulations, Plasma and Urine. Anal Sci. 2016;32(7):763-8. doi: 10.2116/analsci.32.763. PubMed PMID: 27396658.

6: Ghaleiha A, Shahidi KM, Afzali S, Matinnia N. Effect of terazosin on sweating in patients with major depressive disorder receiving sertraline: a randomized controlled trial. Int J Psychiatry Clin Pract. 2013 Feb;17(1):44-7. doi: 10.3109/13651501.2012.687449. Epub 2012 Jun 26. PubMed PMID: 22731399.

7: Liu M, Zhang D, Yang M, Zhao T, Wang X, Zhang Y, Han J, Liu H. Pharmacokinetics of terazosin enantiomers in healthy Chinese male subjects. Chirality. 2012 Dec;24(12):1047-50. doi: 10.1002/chir.22095. Epub 2012 Aug 9. PubMed PMID: 22887707.

8: Chen X, Zhao C, Li X, Wang T, Li Y, Cao C, Ding Y, Dong M, Finci L, Wang JH, Li X, Liu L. Terazosin activates Pgk1 and Hsp90 to promote stress resistance. Nat Chem Biol. 2015 Jan;11(1):19-25. doi: 10.1038/nchembio.1657. Epub 2014 Nov 10. PubMed PMID: 25383758; PubMed Central PMCID: PMC4412158.

9: Mitropoulos D, Patris E, Deliconstantinos G, Kyroudi-Voulgari A, Anastasiou I, Perea D. Terazosin-induced alterations in catalase expression and lipid peroxidation in the rat seminal vesicles. Andrologia. 2013 Apr;45(2):128-34. doi: 10.1111/j.1439-0272.2012.01324.x. Epub 2012 Jun 26. PubMed PMID: 22731390.

10: Mago R, Thase ME, Rovner BW. Antidepressant-induced excessive sweating: clinical features and treatment with terazosin. Ann Clin Psychiatry. 2013 Aug;25(3):186-92. Epub 2013 May 1. PubMed PMID: 23638448.

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