Tiaramide hydrochloride
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MedKoo CAT#: 328302

CAS#: 35941-71-0 (HCl)

Description: Tiaramide hydrochloride, also known as Tiaramide and FK-1160, is an anti-inflammatory drug that inhibits the action of mediators released from mast cells and has direct smooth muscle relaxant properties. It may therefore have a beneficial effect in asthma.


Chemical Structure

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Tiaramide hydrochloride
CAS# 35941-71-0 (HCl)

Theoretical Analysis

MedKoo Cat#: 328302
Name: Tiaramide hydrochloride
CAS#: 35941-71-0 (HCl)
Chemical Formula: C15H19Cl2N3O3S
Exact Mass:
Molecular Weight: 392.295
Elemental Analysis: C, 45.93; H, 4.88; Cl, 18.07; N, 10.71; O, 12.23; S, 8.17

Price and Availability

Size Price Availability Quantity
25.0mg USD 400.0 2 Weeks
100.0mg USD 1100.0 2 Weeks
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Related CAS #: 35941-71-0 (HCl)   32527-55-2 (free base)    

Synonym: Tiaramide hydrochloride; tiaramide; FK-1160; FK 1160; FK1160; NTA-194; NTA194; NTA 194

IUPAC/Chemical Name: 5-chloro-3-(2-(4-(2-hydroxyethyl)piperazin-1-yl)-2-oxoethyl)benzo[d]thiazol-2(3H)-one hydrochloride

InChi Key: UKNGDQSYPNBJAO-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H18ClN3O3S.ClH/c16-11-1-2-13-12(9-11)19(15(22)23-13)10-14(21)18-5-3-17(4-6-18)7-8-20;/h1-2,9,20H,3-8,10H2;1H

SMILES Code: O=C1SC2=CC=C(Cl)C=C2N1CC(N3CCN(CCO)CC3)=O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 392.295 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Takano S. Inhibition of phospholipase A2 by tiaramide in rabbit platelets. Jpn J Pharmacol. 1985 Nov;39(3):307-16. PubMed PMID: 3005729.

2: Iwasaki K, Noguchi H, Kamataki T, Kato R. Metabolism of tiaramide in vitro. I. Oxidative metabolism of tiaramide by human and rat liver microsomes. Xenobiotica. 1982 Apr;12(4):221-6. PubMed PMID: 7113258.

3: Takano S, Sakurai K, Suzuki T. Inhibitory effect of tiaramide of aggregation in vivo and on electrophoresis of rabbit platelets. Jpn J Pharmacol. 1980 Dec;30(6):905-12. PubMed PMID: 6264190.

4: Harvey JE, Jones P, Tanser AR. A trial of tiaramide in asthma. Allergy. 1985 Apr;40(3):198-201. PubMed PMID: 3887976.

5: Khandwala A, Coutts S, Weinryb I. Antiallergic activity of tiaramide (RHC 2592-A). Int Arch Allergy Appl Immunol. 1982;69(2):159-68. PubMed PMID: 6179887.

6: Nakahata N, Nakanishi H. Bradykinin-induced contraction is inhibited by tiaramide, an anti-inflammatory drug, with an inhibition of increase in intracellular free calcium. J Pharmacol Exp Ther. 1988 Aug;246(2):635-40. PubMed PMID: 3136243.

7: Berkin KE, Kerr JW. Tiaramide--a new oral drug for the treatment of asthma. Br J Clin Pharmacol. 1982 Oct;14(4):505-8. PubMed PMID: 7138736; PubMed Central PMCID: PMC1427614.

8: Noguchi H, Iwasaki K. Metabolism of tiaramide in vitro. II. Oxidation of piperazineethanol group in tiaramide by 105 000 g supernatants from monkey and rat liver. Xenobiotica. 1982 Aug;12(8):499-508. PubMed PMID: 6755927.

9: Nabe T, Hashii H, Matsubara S, Yasui K, Yamamura H, Horiba M, Watanabe-Kohno S, Ohata K. A tiaramide derivative, 5-chloro-3-(4-hydroxypiperadinocarbonylmethyl)benzothiazoline-2-one (HPR-611), a potent inhibitor of anaphylactic chemical mediator release--a distinctive feature from disodium cromoglycate. J Pharmacobiodyn. 1992 Dec;15(12):673-9. PubMed PMID: 1284281.

10: Klunk LJ, Riska PS, Maynard DE. The disposition and metabolism of 14C-tiaramide . HCl in man. Drug Metab Dispos. 1982 May-Jun;10(3):241-5. PubMed PMID: 6125356.



Additional Information

Related CAS#

35941-71-0 (HCl)
32527-55-2 (free base)