LB-80317

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526867

CAS#: 441785-24-6

Description: LB-80317, also known as ANA-317, is a DNA polymerase inhibitor potentially for the potential treatment of hepatitis B virus infection.


Chemical Structure

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LB-80317
CAS# 441785-24-6

Theoretical Analysis

MedKoo Cat#: 526867
Name: LB-80317
CAS#: 441785-24-6
Chemical Formula: C10H14N5O5P
Exact Mass: 315.07
Molecular Weight: 315.226
Elemental Analysis: C, 38.10; H, 4.48; N, 22.22; O, 25.38; P, 9.83

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: ANA-317; ANA 317; ANA317; LB-80317; LB 80317; LB80317.

IUPAC/Chemical Name: O=C1NC(N)=NC2=C1N=CN2CC3(OCP(O)(O)=O)CC3

InChi Key: IMAMTECZRBMXGW-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H14N5O5P/c11-9-13-7-6(8(16)14-9)12-4-15(7)3-10(1-2-10)20-5-21(17,18)19/h4H,1-3,5H2,(H2,17,18,19)(H3,11,13,14,16)

SMILES Code: O=C1NC(N)=NC2=C1N=CN2CC3(OCP(O)(O)=O)CC3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 315.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Jung JA, Kim SR, Kim TE, Kim JR, Lee SY, Huh W, Ko JW. Pharmacokinetic
comparison of the maleate and free base formulations of LB80380, a novel
nucleotide analog, in healthy male volunteers. Int J Clin Pharmacol Ther. 2012
Sep;50(9):657-64. PubMed PMID: 22981147.


2: Yuen MF, Lee SH, Kang HM, Kim CR, Kim J, Ngai V, Lai CL. Pharmacokinetics of
LB80331 and LB80317 following oral administration of LB80380, a new antiviral
agent for chronic hepatitis B (CHB), in healthy adult subjects, CHB patients, and
mice. Antimicrob Agents Chemother. 2009 May;53(5):1779-85. doi:
10.1128/AAC.01290-08. Epub 2009 Feb 17. PubMed PMID: 19223649; PubMed Central
PMCID: PMC2681521.


3: Yuen MF, Kim J, Kim CR, Ngai V, Yuen JC, Min C, Kang HM, Shin BS, Yoo SD, Lai
CL. A randomized placebo-controlled, dose-finding study of oral LB80380 in
HBeAg-positive patients with chronic hepatitis B. Antivir Ther.
2006;11(8):977-83. PubMed PMID: 17302367.