Zotepine | CAS#26615-21-4 |

Zotepine
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 328201

CAS#: 26615-21-4

Description: Zotepine is a second generation antipsychotic with a primary use as a treatment for schizophrenia, although clinical trials have been conducted (with positive results) into its efficacy as an antimanic agent in patients with acute bipolar mania.

Chemical Structure

Zotepine

CAS# 26615-21-4

Instruction

Theoretical Analysis

MedKoo Cat#: 328201
Name: Zotepine
CAS#: 26615-21-4
Chemical Formula: C18H18ClNOS
Exact Mass: 331.08
Molecular Weight: 331.858
Elemental Analysis: C, 65.15; H, 5.47; Cl, 10.68; N, 4.22; O, 4.82; S, 9.66

Price and Availability

Size	Price	Availability
10mg	USD 285	2 weeks
25mg	USD 550	2 weeks
50mg	USD 950	2 weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Zotepine

IUPAC/Chemical Name: 2-((8-chlorodibenzo[b,f]thiepin-10-yl)oxy)-N,N-dimethylethan-1-amine

InChi Key: HDOZVRUNCMBHFH-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H18ClNOS/c1-20(2)9-10-21-16-11-13-5-3-4-6-17(13)22-18-8-7-14(19)12-15(16)18/h3-8,11-12H,9-10H2,1-2H3

SMILES Code: ClC1=CC=C(SC2=CC=CC=C2C=C3OCCN(C)C)C3=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 331.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Chan HY, Lin AS, Chen KP, Cheng JS, Chen YY, Tsai CJ. An open-label, randomized, controlled trial of zotepine and risperidone for acutely ill, hospitalized, schizophrenic patients with symptoms of agitation. J Clin Psychopharmacol. 2013 Dec;33(6):747-52. doi: 10.1097/JCP.0b013e31829e8168. PubMed PMID: 24100785.

2: Lin CC, Chiu HJ, Chen JY, Liou YJ, Wang YC, Chen TT, Bai YM. Switching from clozapine to zotepine in patients with schizophrenia: a 12-week prospective, randomized, rater blind, and parallel study. J Clin Psychopharmacol. 2013 Apr;33(2):211-4. doi: 10.1097/JCP.0b013e31828700c7. PubMed PMID: 23422395.

3: Khairkar P, Gupta N, Varma SK. Zotepine-induced convulsive seizures in a chronic case of treatment resistant paranoid schizophrenia. Indian J Pharmacol. 2013 Jan-Feb;45(1):95-7. doi: 10.4103/0253-7613.106447. PubMed PMID: 23543675; PubMed Central PMCID: PMC3608308.

4: Chen IM, Hsieh MH, Hwang TJ, Liu CC. Zotepine-related myopathy in a patient with schizophrenia. Eur J Clin Pharmacol. 2013 Mar;69(3):725-6. doi: 10.1007/s00228-012-1346-y. Epub 2012 Jul 14. PubMed PMID: 22797903.

5: Pai MS, Yang SN, Shiah IS. Rifampin-zotepine interaction reduces effectiveness of antipsychotic drugs in a stable schizophrenia patient. Psychiatry Clin Neurosci. 2012 Oct;66(6):538. doi: 10.1111/j.1440-1819.2012.02370.x. PubMed PMID: 23066778.

6: Subramanian S, Rummel-Kluge C, Hunger H, Schmid F, Schwarz S, Kissling W, Leucht S, Komossa K. Zotepine versus other atypical antipsychotics for schizophrenia. Cochrane Database Syst Rev. 2010 Oct 6;(10):CD006628. doi: 10.1002/14651858.CD006628.pub3. Review. PubMed PMID: 20927748; PubMed Central PMCID: PMC4161491.

7: Huang WL, Chang LR. Hyperhidrosis under combination of zotepine and haloperidol alleviated by aripiprazole. Psychiatry Clin Neurosci. 2012 Apr;66(3):245. doi: 10.1111/j.1440-1819.2012.02328.x. PubMed PMID: 22443252.

8: Suzuki Y, Watanabe J, Sugai T, Fukui N, Ono S, Tsuneyama N, Saito M, Someya T. Improvement in QTc prolongation induced by zotepine following a switch to perospirone. Psychiatry Clin Neurosci. 2012 Apr;66(3):244. doi: 10.1111/j.1440-1819.2012.02321.x. PubMed PMID: 22443250.

9: Hsu WY, Kuo SY, Huang SS, Chang TG, Chiu NY. Valproate and high dosage of zotepine induced acute delirium: a case report. Br J Clin Pharmacol. 2012 Mar;73(3):486-8. doi: 10.1111/j.1365-2125.2011.04119.x. PubMed PMID: 21988532; PubMed Central PMCID: PMC3370356.

10: Hsu WC, Lin ST, Chen CC, Tsang HY, Huang MF. A self-limiting case of atypical neuroleptic malignant syndrome associated with zotepine. J Clin Psychopharmacol. 2011 Oct;31(5):667-9. doi: 10.1097/JCP.0b013e31822c2a04. PubMed PMID: 21881455.

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