Beloxepin
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 326881

CAS#: 135928-30-2

Description: Beloxepin, also known as ADL-6906; ORG-4428, is an oral dual selective serotonin and norepinephrine uptake inhibitor.


Chemical Structure

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Beloxepin
CAS# 135928-30-2

Theoretical Analysis

MedKoo Cat#: 326881
Name: Beloxepin
CAS#: 135928-30-2
Chemical Formula: C19H21NO2
Exact Mass: 295.16
Molecular Weight: 295.382
Elemental Analysis: C, 77.26; H, 7.17; N, 4.74; O, 10.83

Price and Availability

Size Price Availability Quantity
1mg USD 190 Ready to ship
5mg USD 750 Ready to ship
10mg USD 1250 Ready to ship
25mg USD 2250 Ready to ship
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Synonym: ADL-6906; ADL 6906; ADL6906; ORG-4428; ORG4428; ORG 4428; Beloxepin.

IUPAC/Chemical Name: cis-1,3,4,13b-Tetrahydro-2,10-dimethyldibenz(2,3:6,7)oxepino(4,5-c)pyridin-4a(2H)-ol

InChi Key: RPMDQAYGQBREBS-VQIMIIECSA-N

InChi Code: InChI=1S/C19H21NO2/c1-13-6-5-7-14-16-12-20(2)11-10-19(16,21)15-8-3-4-9-17(15)22-18(13)14/h3-9,16,21H,10-12H2,1-2H3/t16-,19-/m1/s1

SMILES Code: O[C@]12[C@](C3=CC=CC(C)=C3OC4=CC=CC=C42)([H])CN(C)CC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target: Beloxepin, also known as ADL-6906; ORG-4428, is an oral dual selective serotonin and norepinephrine uptake inhibitor.
In vitro activity: TBD
In vivo activity: TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 295.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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1: Fujimaki K, Morinobu S, Duman RS. Administration of a cAMP phosphodiesterase 4 inhibitor enhances antidepressant-induction of BDNF mRNA in rat hippocampus. Neuropsychopharmacology. 2000 Jan;22(1):42-51. doi: 10.1016/S0893-133X(99)00084-6. PMID: 10633490.


2: van Bemmel AL, Vermeeren MT, Ruigt G, Sennef C. The acute effects of the noradrenaline reuptake inhibitor Org 4428 on EEG sleep in healthy volunteers. Neuropsychobiology. 1999;40(2):107-14. doi: 10.1159/000026605. PMID: 10474065.


3: Paanakker JE, de Jong J, Thio JM, van Hal HJ. Validation of an LC-MS assay for the quantification of the enantiomers of Org 4428 in human plasma. J Pharm Biomed Anal. 1998 Feb;16(6):981-9. doi: 10.1016/s0731-7085(97)00113-1. PMID: 9547701.


4: Inoue T, Hashimoto S, Tsuchiya K, Izumi T, Ohmori T, Koyama T. Effect of citalopram, a selective serotonin reuptake inhibitor, on the acquisition of conditioned freezing. Eur J Pharmacol. 1996 Sep 5;311(1):1-6. doi: 10.1016/0014-2999(96)00391-3. PMID: 8884229.