WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 327032
Description: Vorolanib, also known as CM-082 and X-82, is small molecule dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and platelet-derived growth factor receptors (PDGFRs) with antiangiogenic and antineoplastic activities. VEGFR/PDGFR dual kinase inhibitor Vorolanib inhibits all isoforms of VEGFR and PDGFR, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Both VEGFRs and PDGFRs are receptor tyrosine kinases that may be upregulated in various tumor cell types. VEGFR/PDGFR dual kinase inhibitor Vorolanib has been shown to reduce tissue toxicity by 95 percent compared with first-generation kinase inhibitors.
MedKoo Cat#: 327032
Chemical Formula: C23H26FN5O3
Exact Mass: 439.202
Molecular Weight: 439.4914
Elemental Analysis: C, 62.86; H, 5.96; F, 4.32; N, 15.94; O, 10.92
Synonym: Vorolanib, CM-082, X-82, CM082, X82, CM 082, X 82
IUPAC/Chemical Name: (S,Z)-N-(1-(dimethylcarbamoyl)pyrrolidin-3-yl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
InChi Key: KMIOJWCYOHBUJS-HAKPAVFJSA-N
InChi Code: InChI=1S/C23H26FN5O3/c1-12-19(10-17-16-9-14(24)5-6-18(16)27-21(17)30)25-13(2)20(12)22(31)26-15-7-8-29(11-15)23(32)28(3)4/h5-6,9-10,15,25H,7-8,11H2,1-4H3,(H,26,31)(H,27,30)/b17-10-/t15-/m0/s1
SMILES Code: CN(C)C(=O)N1CC[C@@H](C1)NC(=O)C1=C(C)NC(\C=C2/C(=O)NC3=C2C=C(F)C=C3)=C1C