PD-89211

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MedKoo CAT#: 525909

CAS#: 444725-49-9

Description: PD-89211 is a selective dopamine D4 receptor antagonist. PD 89211 exhibits high selectivity for the DA D4.2 receptor (> 800-fold) as compared to other hDA receptor subtypes, rat brain serotonin, and adrenergic receptors. In vitro, PD 89211 had D4 receptor antagonist activity reversing quinpirole-induced [3H]thymidine uptake in CHOpro5 cells (IC50 = 2.1 nM).


Chemical Structure

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PD-89211
CAS# 444725-49-9

Theoretical Analysis

MedKoo Cat#: 525909
Name: PD-89211
CAS#: 444725-49-9
Chemical Formula: C19H21ClN4O
Exact Mass: 356.14
Molecular Weight: 356.850
Elemental Analysis: C, 63.95; H, 5.93; Cl, 9.93; N, 15.70; O, 4.48

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: PD-89211; PD 89211; PD89211.

IUPAC/Chemical Name: Benzenemethanol, 4-(4-(1H-benzimidazol-2-ylmethyl)-1-piperazinyl)-2-chloro-

InChi Key: HGMLOQOHAYKVJN-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H21ClN4O/c20-16-11-15(6-5-14(16)13-25)24-9-7-23(8-10-24)12-19-21-17-3-1-2-4-18(17)22-19/h1-6,11,25H,7-10,12-13H2,(H,21,22)

SMILES Code: c1ccc2c(c1)[nH]c(n2)CN3CCN(CC3)c4ccc(c(c4)Cl)CO

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 356.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Pugsley TA, Shih YH, Whetzel SZ, Zoski K, Van Leeuwen D, Akunne H, Mackenzie R, Heffner TG, Wustrow D, Wise LD. The discovery of PD 89211 and related compounds: selective dopamine D4 receptor antagonists. Prog Neuropsychopharmacol Biol Psychiatry. 2002 Feb;26(2):219-26. PubMed PMID: 11817497.