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MedKoo CAT#: 526834

CAS#: 1541206-05-6

Description: BU09059 is a potent, selective, short-acting (non-"inactivating") antagonist of the κ-opioid receptor (KOR). It was derived from the irreversible (long-acting) KOR antagonist JDTic in search of an antagonist with a reversible profile of inactivation of the KOR that could be used with less concern to treat psychiatric disorders. In addition to its reversibility, BU09059 is much more selective for the KOR than JDTic, showing 15-fold and 616-fold preference for the KOR over the μ- and δ-opioid receptors (Ki = 1.72 nM, 26.5 nM, and 1060 nM, respectively).

Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-03-30. Prices are subject to change without notice.

BU09059 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 526834
Name: BU09059
CAS#: 1541206-05-6
Chemical Formula: C28H37N3O5
Exact Mass: 495.2733
Molecular Weight: 495.62
Elemental Analysis: C, 67.86; H, 7.53; N, 8.48; O, 16.14

Synonym: BU09059; BU-09059; BU 09059.

IUPAC/Chemical Name: ethyl 2-{[(3R)-7-hydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]formamido}-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]propanoate


InChi Code: InChI=1S/C28H37N3O5/c1-4-36-27(35)25(30-26(34)24-13-19-8-9-23(33)12-20(19)15-29-24)17-31-11-10-28(3,18(2)16-31)21-6-5-7-22(32)14-21/h5-9,12,14,18,24-25,29,32-33H,4,10-11,13,15-17H2,1-3H3,(H,30,34)/t18-,24+,25?,28+/m0/s1

SMILES Code: O=C(OCC)C(NC([C@@H]1NCC2=C(C=CC(O)=C2)C1)=O)CN3C[C@H](C)[C@](C)(C4=CC=CC(O)=C4)CC3

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Casal-Dominguez JJ, Furkert D, Ostovar M, Teintang L, Clark MJ, Traynor JR,
Husbands SM, Bailey SJ. Characterization of BU09059: a novel potent selective
κ-receptor antagonist. ACS Chem Neurosci. 2014 Mar 19;5(3):177-84. doi:
10.1021/cn4001507. Epub 2014 Jan 28. PubMed PMID: 24410326; PubMed Central PMCID: