WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406812
CAS#: 68637-19-4 (free acid)
Description: Aluminum phthalocyanine disulfonate sodium, also known as AlPcS2 disodium or AlS2Pc or AlPcS(2a), is a potent photosensitizer, and is potentially useful in cancer sonodynamic therapy and cancer photodynamic therapy. Aluminum phthalocyanine disulfonate is a mixture of regional isomers, in which sulfonate group can be in 3- or 4- position in phenyl ring. Aluminum phthalocyanine disulfonate is also a Coloring Agent; Dermatologic Agent; Fluorescent Dye; Indicators and Reagent; Luminescent Agent; Photosensitizing Agent; Radiation-Sensitizing Agent.
MedKoo Cat#: 406812
Name: Aluminum phthalocyanine disulfonate disodium
CAS#: 68637-19-4 (free acid)
Chemical Formula: C32H14AlClN8Na2O6S2
Exact Mass:
Molecular Weight: 779.0451
Elemental Analysis: C, 49.34; H, 1.81; Al, 3.46; Cl, 4.55; N, 14.38; Na, 5.90; O, 12.32; S, 8.23
Synonym: Aluminum phthalocyanine disulfonate disodium; AlPcS(2a), AlPcS2; AlS2Pc; ClAlPcS2. Clalpcs; Disulfonated aluminum phthalocyanine; Al(III) Phthalocyanine chloride disulfonate disodium
IUPAC/Chemical Name: Aluminate(2-), chloro[29H,31H-phthalocyanine-C,C-disulfonato(4-)-κN29,κN30,κN31,κN32]-, sodium(1:2)
InChi Key: NHVAKUAEQKVVJJ-UHFFFAOYSA-K
InChi Code: InChI=1S/C32H16N8O6S2.Al.ClH.2Na/c41-47(42,43)15-9-11-21-23(13-15)31-38-29(21)36-27-19-7-3-1-5-17(19)25(34-27)33-26-18-6-2-4-8-20(18)28(35-26)37-30-22-12-10-16(48(44,45)46)14-24(22)32(39-30)40-31;;;;/h1-14H,(H2-2,33,34,35,36,37,38,39,40,41,42,43,44,45,46);;1H;;/q-2;+3;;2*+1/p-3
SMILES Code: Cl[Al]123N(C(C4=C5C=CC=C4)=N6)C5=NC7=[N]1C(C8=C7C=CC(S(=O)(O[Na])=O)=C8)=NC(N93)=C%10C=C(S(=O)(O[Na])=O)C=CC%10=C9N=C%11C%12=C(C=CC=C%12)C6=[N]%112
Appearance: Deep blue to black solid powder
Purity: >90% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in water.
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in water
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
| Biological target: | N/A |
| In vitro activity: | As seen in the diagrams, cells in control group 1 that comprised of cells neither treated with AlPcSmix (sulfonated aluminum phthalocyanine mix) nor exposed to light appeared structurally unaltered and retained their characteristic morphology after 24 hours of incubation. The cells appeared healthy and uninjured and actively proliferated to confluence in 24 hours. PDT treated cells on the other hand (AlPcSmix+ irradiation) showed visible structural alteration with increasing level of damage proportional to the increase in PDT doses. Although there was significant cell damage in both cell populations, the side population incurred less damage than the total cell population at similar dose concentrations. There was however observable cell morphology alterations showing cell shrinkage, blebbing and detachment from the plate surface. Reference: Oncotarget. 2019 Jul 9; 10(43): 4380–4396. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6633885/ |
| In vivo activity: | On the one hand, in comparison to control, mice injected with cells treated with PDT mediated by IC50 and IC70 AlPcNE (aluminum phthalocyanine) exhibited a delay in tumor development, which is even comparable to that induced by ICD-positive, MTX-treated cells (Fig. 4B). The increased resistance to tumor development was also reflected in the survival curves, as the mice injected with B16F10 cells treated with MTX or with PDT mediated by IC50 or IC70 AlPcNE showed higher survival rates than mice from the other groups (Fig. 4C-D). Reference: Photodiagnosis Photodyn Ther. 2021 Jun 13;35:102392. https://pubmed.ncbi.nlm.nih.gov/34133961/ |
The following data is based on the product molecular weight 779.0451 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | 1. Tang WZ, Cui ZJ. Permanent Photodynamic Activation of the Cholecystokinin 2 Receptor. Biomolecules. 2020 Feb 4;10(2):236. doi: 10.3390/biom10020236. PMID: 32033232; PMCID: PMC7072308. 2. Chizenga EP, Chandran R, Abrahamse H. Photodynamic therapy of cervical cancer by eradication of cervical cancer cells and cervical cancer stem cells. Oncotarget. 2019 Jul 9;10(43):4380-4396. doi: 10.18632/oncotarget.27029. PMID: 31320992; PMCID: PMC6633885. 3. Morais JAV, Almeida LR, Rodrigues MC, Azevedo RB, Muehlmann LA. The induction of immunogenic cell death by photodynamic therapy in B16F10 cells in vitro is effected by the concentration of the photosensitizer. Photodiagnosis Photodyn Ther. 2021 Jun 13;35:102392. doi: 10.1016/j.pdpdt.2021.102392. Epub ahead of print. PMID: 34133961. 4. Longo JP, Lozzi SP, Simioni AR, Morais PC, Tedesco AC, Azevedo RB. Photodynamic therapy with aluminum-chloro-phthalocyanine induces necrosis and vascular damage in mice tongue tumors. J Photochem Photobiol B. 2009 Feb 9;94(2):143-6. doi: 10.1016/j.jphotobiol.2008.11.003. Epub 2008 Nov 21. PMID: 19097802. |
| In vitro protocol: | 1. Tang WZ, Cui ZJ. Permanent Photodynamic Activation of the Cholecystokinin 2 Receptor. Biomolecules. 2020 Feb 4;10(2):236. doi: 10.3390/biom10020236. PMID: 32033232; PMCID: PMC7072308. 2. Chizenga EP, Chandran R, Abrahamse H. Photodynamic therapy of cervical cancer by eradication of cervical cancer cells and cervical cancer stem cells. Oncotarget. 2019 Jul 9;10(43):4380-4396. doi: 10.18632/oncotarget.27029. PMID: 31320992; PMCID: PMC6633885. |
| In vivo protocol: | 1. Morais JAV, Almeida LR, Rodrigues MC, Azevedo RB, Muehlmann LA. The induction of immunogenic cell death by photodynamic therapy in B16F10 cells in vitro is effected by the concentration of the photosensitizer. Photodiagnosis Photodyn Ther. 2021 Jun 13;35:102392. doi: 10.1016/j.pdpdt.2021.102392. Epub ahead of print. PMID: 34133961. 2. Longo JP, Lozzi SP, Simioni AR, Morais PC, Tedesco AC, Azevedo RB. Photodynamic therapy with aluminum-chloro-phthalocyanine induces necrosis and vascular damage in mice tongue tumors. J Photochem Photobiol B. 2009 Feb 9;94(2):143-6. doi: 10.1016/j.jphotobiol.2008.11.003. Epub 2008 Nov 21. PMID: 19097802. |
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