WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 206616
CAS#: 1365267-27-1 (X376)
Description: X-376 is an ALK inhibitor and potentially useful in non-small cell lung cancer. Caution: Many vendora are mistakenly selling X-376 as Ensartinib (X396, X-396, X 396). The structure is slightly different (see Cat#206013)
MedKoo Cat#: 206616
Name: X-376
CAS#: 1365267-27-1 (X376)
Chemical Formula: C25H25Cl2FN6O3
Exact Mass: 546.1349
Molecular Weight: 547.4124
Elemental Analysis: C, 54.85; H, 4.60; Cl, 12.95; F, 3.47; N, 15.35; O, 8.77
Related CAS #: 1370651-20-9 (X396) 1365267-27-1 (X376)
Synonym: X-376; X 376; X376; Ensartinib-analog; X 396-analog; X396-analog; X-396-analog;
IUPAC/Chemical Name: 6-Amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-3-pyridazinecarboxamide
InChi Key: ONPGOSVDVDPBCY-CQSZACIVSA-N
InChi Code: InChI=1S/C25H25Cl2FN6O3/c1-14(21-17(26)7-8-18(28)22(21)27)37-20-13-19(31-32-23(20)29)24(35)30-16-5-3-15(4-6-16)25(36)34-11-9-33(2)10-12-34/h3-8,13-14H,9-12H2,1-2H3,(H2,29,32)(H,30,35)/t14-/m1/s1
SMILES Code: O=C(C1=NN=C(N)C(O[C@@H](C2=C(Cl)C=CC(F)=C2Cl)C)=C1)NC3=CC=C(C(N4CCN(C)CC4)=O)C=C3
1: Sullivan I, Planchard D. ALK inhibitors in non-small cell lung cancer: the latest evidence and developments. Ther Adv Med Oncol. 2016 Jan;8(1):32-47. doi: 10.1177/1758834015617355. Review. PubMed PMID: 26753004; PubMed Central PMCID: PMC4699265.
2: Qiu W, Yuchi M, Ding M, Tessier D, Fenster A. Needle segmentation using 3D Hough transform in 3D TRUS guided prostate transperineal therapy. Med Phys. 2013 Apr;40(4):042902. doi: 10.1118/1.4795337. PubMed PMID: 23556924.
3: Lovly CM, Heuckmann JM, de Stanchina E, Chen H, Thomas RK, Liang C, Pao W. Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinase inhibitors. Cancer Res. 2011 Jul 15;71(14):4920-31. doi: 10.1158/0008-5472.CAN-10-3879. Epub 2011 May 25. PubMed PMID: 21613408; PubMed Central PMCID: PMC3138877.
4: Byrne PV. Human myeloid cells possessing high-affinity receptors for granulocyte-macrophage colony stimulating factor. Leuk Res. 1989;13(2):117-26. PubMed PMID: 2538682.