PD 138142

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525845

CAS#: 142642-31-7

Description: PD 138142 is a water soluble inhibitor of ACAT. Triacylglycerol secretion is decreased in the presence of PD-138142-15.


Chemical Structure

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PD 138142
CAS# 142642-31-7

Theoretical Analysis

MedKoo Cat#: 525845
Name: PD 138142
CAS#: 142642-31-7
Chemical Formula: C25H35NO5S
Exact Mass: 461.22
Molecular Weight: 461.614
Elemental Analysis: C, 65.05; H, 7.64; N, 3.03; O, 17.33; S, 6.95

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: PD-138142; PD138142; PD 138142

IUPAC/Chemical Name: 2,6-diisopropylphenyl (2,6-diisopropylphenoxy)carbonylsulfamate

InChi Key: MHCQGCLTFBMETG-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H35NO5S/c1-15(2)19-11-9-12-20(16(3)4)23(19)30-25(27)26-32(28,29)31-24-21(17(5)6)13-10-14-22(24)18(7)8/h9-18H,1-8H3,(H,26,27)

SMILES Code: O=C(OC1=C(C(C)C)C=CC=C1C(C)C)NS(=O)(OC2=C(C(C)C)C=CC=C2C(C)C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 461.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Carr TP, Hamilton RL Jr, Rudel LL. ACAT inhibitors decrease secretion of cholesteryl esters and apolipoprotein B by perfused livers of African green monkeys. J Lipid Res. 1995 Jan;36(1):25-36. PubMed PMID: 7706945.
2: Wolfgang GH, Robertson DG, Welty DF, Metz AL. Hepatic and adrenal toxicity of a novel lipid regulator in beagle dogs. Fundam Appl Toxicol. 1995 Jul;26(2):272-81. PubMed PMID: 7589916.
3: Robertson DG, Krause BR, Welty DF, Wolfgang GH, Graziano MJ, Pilcher GD, Urda E. Hepatic microsomal induction profile of carbamic acid [[2,6-bis(1- methylethyl)phenoxy] sulfonyl]-2,6-bis(1-methylethyl) phenyl ester, monosodium salt (PD138142-15), a novel lipid regulating agent. Biochem Pharmacol. 1995 Mar 15;49(6):799-808. PubMed PMID: 7702638.
4: Diczfalusy MA, Björkhem I, Einarsson K, Alexson SE. Acyl-coenzyme A:cholesterol O-acyltransferase is not identical to liver microsomal carboxylesterase. Arterioscler Thromb Vasc Biol. 1996 Apr;16(4):606-10. PubMed PMID: 8624784.
5: Kodvawala A, Ghering AB, Davidson WS, Hui DY. Carboxyl ester lipase expression in macrophages increases cholesteryl ester accumulation and promotes atherosclerosis. J Biol Chem. 2005 Nov 18;280(46):38592-8. Epub 2005 Sep 14. PubMed PMID: 16166077.
6: Sliskovic DR, Krause BR, Picard JA, Anderson M, Bousley RF, Hamelehle KL, Homan R, Julian TN, Rashidbaigi ZA, Stanfield RL. Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity. J Med Chem. 1994 Mar 4;37(5):560-2. PubMed PMID: 8126693.