Lanicemine (free base)
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MedKoo CAT#: 525425

CAS#: 153322-05-5

Description: Lanicemine (free base) is a low-trapping NMDA receptor antagonist. Lanicemine is used the management of severe and treatment-resistant depression. Lanicemine was originally developed as a neuroprotective agent, but was redeveloped as an antidepressant.


Price and Availability

Size Price Shipping out time Quantity
10mg USD 240 2 Weeks
25mg USD 440 2 Weeks
50mg USD 810 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-04-09. Prices are subject to change without notice.

Lanicemine, purity > 95%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 525425
Name: Lanicemine (free base)
CAS#: 153322-05-5
Chemical Formula: C13H14N2
Exact Mass: 198.1157
Molecular Weight: 198.26
Elemental Analysis: C, 78.75; H, 7.12; N, 14.13


Synonym: Lanicemine(free base); Lanicemine(2HCl) ARL-15896; ARL-15896AR; ARR-15896; ARR-15896AR; FPL-15896; FPL-15896AR ARL15896; ARL15896AR; ARR15896; ARR15896AR; FPL15896; FPL15896AR ARL 15896; ARL 15896AR; ARR 15896; ARR 15896AR; FPL 15896; FPL 15896AR

IUPAC/Chemical Name: (S)-1-phenyl-2-(pyridin-2-yl)ethanamine

InChi Key: FWUQWDCOOWEXRY-ZDUSSCGKSA-N

InChi Code: InChI=1S/C13H14N2/c14-13(11-6-2-1-3-7-11)10-12-8-4-5-9-15-12/h1-9,13H,10,14H2/t13-/m0/s1

SMILES Code: N[C@H](c1ccccc1)Cc2ncccc2


Technical Data

Appearance:
Liquid

Purity:
>95% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


Additional Information

Related CAS#
153322-05-5(Lanicemine free base)
153322-06-6(Lanicemine dihydrochloride)


References

1: Wallach J, Kang H, Colestock T, Morris H, Bortolotto ZA, Collingridge GL, Lodge D, Halberstadt AL, Brandt SD, Adejare A. Pharmacological Investigations of the Dissociative 'Legal Highs' Diphenidine, Methoxphenidine and Analogues. PLoS One. 2016 Jun 17;11(6):e0157021. doi: 10.1371/journal.pone.0157021. eCollection 2016. PubMed PMID: 27314670; PubMed Central PMCID: PMC4912077.

2: Downey D, Dutta A, McKie S, Dawson GR, Dourish CT, Craig K, Smith MA, McCarthy DJ, Harmer CJ, Goodwin GM, Williams S, Deakin JF. Comparing the actions of lanicemine and ketamine in depression: key role of the anterior cingulate. Eur Neuropsychopharmacol. 2016 Jun;26(6):994-1003. doi: 10.1016/j.euroneuro.2016.03.006. Epub 2016 Apr 28. PubMed PMID: 27133029.

3: Keavy D, Bristow LJ, Sivarao DV, Batchelder M, King D, Thangathirupathy S, Macor JE, Weed MR. The qEEG Signature of Selective NMDA NR2B Negative Allosteric Modulators; A Potential Translational Biomarker for Drug Development. PLoS One. 2016 Apr 1;11(4):e0152729. doi: 10.1371/journal.pone.0152729. eCollection 2016. PubMed PMID: 27035340; PubMed Central PMCID: PMC4817977.

4: Cooper MD, Rosenblat JD, Cha DS, Lee Y, Kakar R, McIntyre RS. Strategies to mitigate dissociative and psychotomimetic effects of ketamine in the treatment of major depressive episodes: a narrative review. World J Biol Psychiatry. 2016 Mar 16:1-14. [Epub ahead of print] PubMed PMID: 26752601.

5: Fernandes A, Wojcik T, Baireddy P, Pieschl R, Newton A, Tian Y, Hong Y, Bristow L, Li YW. Inhibition of in vivo [(3)H]MK-801 binding by NMDA receptor open channel blockers and GluN2B antagonists in rats and mice. Eur J Pharmacol. 2015 Nov 5;766:1-8. doi: 10.1016/j.ejphar.2015.08.044. Epub 2015 Aug 29. PubMed PMID: 26325093.

6: Rajkumar R, Fam J, Yeo EY, Dawe GS. Ketamine and suicidal ideation in depression: Jumping the gun? Pharmacol Res. 2015 Sep;99:23-35. doi: 10.1016/j.phrs.2015.05.003. Epub 2015 May 15. Review. PubMed PMID: 25982932.

7: Bui KH, Zhou D, Agbo F, Guo J. Effect of multiple intravenous doses of lanicemine (AZD6765) on the pharmacokinetics of midazolam in healthy subjects. J Clin Pharmacol. 2015 Sep;55(9):1024-30. doi: 10.1002/jcph.515. Epub 2015 Jun 2. PubMed PMID: 25880724.

8: Skolnick P, Kos T, Czekaj J, Popik P. Effect of NMDAR antagonists in the tetrabenazine test for antidepressants: comparison with the tail suspension test. Acta Neuropsychiatr. 2015 Aug;27(4):228-34. doi: 10.1017/neu.2015.14. Epub 2015 Apr 10. PubMed PMID: 25858023.

9: Solé B, Jiménez E, Martinez-Aran A, Vieta E. Cognition as a target in major depression: new developments. Eur Neuropsychopharmacol. 2015 Feb;25(2):231-47. doi: 10.1016/j.euroneuro.2014.12.004. Epub 2015 Jan 19. Review. PubMed PMID: 25640673.

10: Guo J, Zhou D, Grimm SW, Bui KH. Pharmacokinetics, metabolism and excretion of [(14)C]-lanicemine (AZD6765), a novel low-trapping N-methyl-d-aspartic acid receptor channel blocker, in healthy subjects. Xenobiotica. 2015 Mar;45(3):244-55. doi: 10.3109/00498254.2014.966175. Epub 2014 Sep 26. PubMed PMID: 25259653.

11: Sanacora G, Smith MA, Pathak S, Su HL, Boeijinga PH, McCarthy DJ, Quirk MC. Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects. Mol Psychiatry. 2014 Sep;19(9):978-85. doi: 10.1038/mp.2013.130. Epub 2013 Oct 15. PubMed PMID: 24126931; PubMed Central PMCID: PMC4195977.

12: Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2003 Jan-Feb;25(1):53-76. PubMed PMID: 12690708.