JNJ-42259152

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525407

CAS#: 1301167-87-2

Description: JNJ-42259152 is a novel phosphodiesterase 10A PET tracer. Kinetic modeling of (18)F-JNJ-42259152 shows that PDE10A activity can be reliably quantified and simplified using a reference tissue model with the frontal cortex as reference and a 60-min acquisition period.


Chemical Structure

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JNJ-42259152
CAS# 1301167-87-2

Theoretical Analysis

MedKoo Cat#: 525407
Name: JNJ-42259152
CAS#: 1301167-87-2
Chemical Formula: C24H23FN4O
Exact Mass: 402.18559
Molecular Weight: 402.46
Elemental Analysis: C, 71.62; H, 5.76; F, 4.72; N, 13.92; O, 3.98

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: JNJ-42259152; JNJ 42259152; JNJ42259152.

IUPAC/Chemical Name: 2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)-3,5-dimethylpyridine

InChi Key: OWEZURWNYQWWNB-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H23FN4O/c1-17-13-18(2)23(27-14-17)16-30-21-5-3-20(4-6-21)24-22(15-29(28-24)12-9-25)19-7-10-26-11-8-19/h3-8,10-11,13-15H,9,12,16H2,1-2H3

SMILES Code: CC1=CN=C(COC2=CC=C(C3=NN(CCF)C=C3C4=CC=NC=C4)C=C2)C(C)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 402.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Van Laere K, Ahmad RU, Hudyana H, Dubois K, Schmidt ME, Celen S, Bormans G, Koole M. Quantification of 18F-JNJ-42259152, a novel phosphodiesterase 10A PET tracer: kinetic modeling and test-retest study in human brain. J Nucl Med. 2013 Aug;54(8):1285-93. doi: 10.2967/jnumed.112.118679. Epub 2013 Jul 10. PubMed PMID: 23843566.