JNJ-26146900

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525316

CAS#: 868691-50-3

Description: JNJ-26146900 is a nonsteroidal androgen receptor (AR) ligand with tissue-selective activity in rats. It binds to the rat AR with a K(i) of 400nM and acts as a pure androgen antagonist in an in vitro cell-based assay. JNJ-26146900 has the potential for anabolic effects on bone and muscle while maintaining therapeutic efficacy in prostate cancer.


Chemical Structure

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JNJ-26146900
CAS# 868691-50-3

Theoretical Analysis

MedKoo Cat#: 525316
Name: JNJ-26146900
CAS#: 868691-50-3
Chemical Formula: C15H15F3N2O3S
Exact Mass: 360.07555
Molecular Weight: 360.35
Elemental Analysis: C, 50.00; H, 4.20; F, 15.82; N, 7.77; O, 13.32; S, 8.90

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: JNJ-26146900; JNJ 26146900; JNJ26146900.

IUPAC/Chemical Name: (-)(R)-2-(2-Ethylsulfonyl-1-hydroxy-1-methylethyl)-6-trifluoromethyl-1H-indole-5-carbonitrile

InChi Key: UJGGNFGSHPHGNE-AWEZNQCLSA-N

InChi Code: InChI=1S/C15H15F3N2O3S/c1-3-24(22,23)8-14(2,21)13-5-9-4-10(7-19)11(15(16,17)18)6-12(9)20-13/h4-6,20-21H,3,8H2,1-2H3/t14-/m0/s1

SMILES Code: N#CC1=CC2=C(NC([C@@](C)(O)CS(=O)(CC)=O)=C2)C=C1C(F)(F)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 360.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Allan G, Lai MT, Sbriscia T, Linton O, Haynes-Johnson D, Bhattacharjee S, Dodds R, Fiordeliso J, Lanter J, Sui Z, Lundeen S. A selective androgen receptor

modulator that reduces prostate tumor size and prevents orchidectomy-induced bone loss in rats. J Steroid Biochem Mol Biol. 2007 Jan;103(1):76-83. Epub 2006 Oct 17. PubMed PMID: 17049844.