WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 525299
Description: JNJ-10258859 is a novel, potent, and selective phosphodiesterase type 5 inhibitor. JNJ-10258859 inhibits phosphodiesterase type 5 with a K(i) of 0.23 nM and displayed excellent selectivity versus phosphodiesterase types 1-4 (>/=22,000 fold compared to phosphodiesterase type 5). JNJ-10258859 could be a useful treatment for erectile dysfunction.
MedKoo Cat#: 525299
Chemical Formula: C30H24N4O3
Exact Mass: 488.18484
Molecular Weight: 488.54
Elemental Analysis: C, 73.76; H, 4.95; N, 11.47; O, 9.82
This product is not in stock, which may be available by custom synthesis.
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Synonym: JNJ-10258859; JNJ 10258859; JNJ10258859; UNII-4NPX9224XR.
IUPAC/Chemical Name: 9H-Pyrrolo(3,4-b)quinolin-9-one, 3-(2,3-dihydro-5-benzofuranyl)-1,2,3,4-tetrahydro-2-(5-(4-methoxyphenyl)-2-pyrimidinyl)-, (3R)-
InChi Key: MVMQGWXVSBNFLB-MUUNZHRXSA-N
InChi Code: InChI=1S/C30H24N4O3/c1-36-22-9-6-18(7-10-22)21-15-31-30(32-16-21)34-17-24-27(33-25-5-3-2-4-23(25)29(24)35)28(34)20-8-11-26-19(14-20)12-13-37-26/h2-11,14-16,28H,12-13,17H2,1H3,(H,33,35)/t28-/m1/s1
SMILES Code: O=C1C2=C([C@@H](C3=CC=C(OCC4)C4=C3)N(C5=NC=C(C6=CC=C(OC)C=C6)C=N5)C2)NC7=C1C=CC=C7
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 488.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Qiu Y, Bhattacharjee S, Kraft P, John TM, Craig E, Haynes-Johnson D, Guan J, Jiang W, Macielag M, Sui Z, Clancy J, Lundeen S. Characterization of a novel phosphodiesterase type 5 inhibitor: JNJ-10258859. Eur J Pharmacol. 2003 Jul 4;472(1-2):73-80. PubMed PMID: 12860475.