WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 525298
Description: JNJ-10229570 is a novel MC1R and MC5R antagonist was used to treat primary human sebaceous cells. It might have a potential for the treatment of acne and other sebaceous gland pathologies.
MedKoo Cat#: 525298
Chemical Formula: C22H19N3O2S
Exact Mass: 389.1198
Molecular Weight: 389.47
Elemental Analysis: C, 67.84; H, 4.92; N, 10.79; O, 8.22; S, 8.23
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: JNJ-10229570; JNJ10229570; JNJ 10229570; UNII-N9IX402L35.
IUPAC/Chemical Name: Benzenamine, N-(2,3-bis(2-methoxyphenyl)-1,2,4-thiadiazol-5(2H)-ylidene)-
InChi Key: XTHRTBCPBWJYRO-GHVJWSGMSA-N
InChi Code: InChI=1S/C22H19N3O2S/c1-26-19-14-8-6-12-17(19)21-24-22(23-16-10-4-3-5-11-16)28-25(21)18-13-7-9-15-20(18)27-2/h3-15H,1-2H3/b23-22+
SMILES Code: COC1=CC=CC=C1C2=N/C(SN2C3=CC=CC=C3OC)=N\C4=CC=CC=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 389.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Eisinger M, Li WH, Anthonavage M, Pappas A, Zhang L, Rossetti D, Huang Q, Seiberg M. A melanocortin receptor 1 and 5 antagonist inhibits sebaceous gland differentiation and the production of sebum-specific lipids. J Dermatol Sci. 2011 Jul;63(1):23-32. doi: 10.1016/j.jdermsci.2011.04.001. Epub 2011 Apr 15. PubMed PMID: 21602033.