WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 326755
CAS#: 30123-17-2 (sodium)
Description: Tianeptine is a drug used primarily in the treatment of major depressive disorder, although it may also be used to treat asthma or irritable bowel syndrome. Chemically it is a tricyclic antidepressant (TCA), but it has different pharmacological properties than typical TCAs as recent research suggests that tianeptine produces its antidepressant effects through indirect alteration of glutamate receptor activity (i.e., AMPA receptors and NMDA receptors) and release of BDNF, in turn affecting neural plasticity.
MedKoo Cat#: 326755
Name: Tianeptine sodium
CAS#: 30123-17-2 (sodium)
Chemical Formula: C21H24ClN2NaO4S
Exact Mass: 436.1224
Molecular Weight: 458.9328
Elemental Analysis: C, 54.96; H, 5.27; Cl, 7.72; N, 6.10; Na, 5.01; O, 13.94; S, 6.99
Related CAS #: 72797-41-2 (free base) 30123-17-2 (sodium)
Synonym: Tianeptine; brand names Stablon, Coaxil, Tatinol, Tianeurax and Salymbra
IUPAC/Chemical Name: sodium 7-((3-chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino)heptanoate
InChi Key: ZLBSUOGMZDXYKE-UHFFFAOYSA-M
InChi Code: InChI=1S/C21H25ClN2O4S.Na/c1-24-18-9-6-5-8-16(18)21(23-13-7-3-2-4-10-20(25)26)17-12-11-15(22)14-19(17)29(24,27)28;/h5-6,8-9,11-12,14,21,23H,2-4,7,10,13H2,1H3,(H,25,26);/q;+1/p-1
SMILES Code: O=C([O-])CCCCCCNC(C1=CC=C(Cl)C=C12)C3=CC=CC=C3N(C)S2(=O)=O.[Na+]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 458.9328 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Uzbekov MG. Antidepressant action of tianeptine is connected with acceleration of serotonin turnover in the synapse: a hypothesis. Neuropsychopharmacol Hung. 2009 Jun;11(2):83-7. Review. PubMed PMID: 19827315.
2: McEwen BS, Chattarji S, Diamond DM, Jay TM, Reagan LP, Svenningsson P, Fuchs E. The neurobiological properties of tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation. Mol Psychiatry. 2010 Mar;15(3):237-49. doi: 10.1038/mp.2009.80. Epub 2009 Aug 25. Review. PubMed PMID: 19704408; PubMed Central PMCID: PMC2902200.
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