TG100572 HCl

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MedKoo CAT#: 406790

CAS#: 867331-64-4 (HCl)

Description: TG-100572 is a potent and selective VEGFR2/Src kinase inhibitor. TG100572 inhibits Src kinases and selected receptor tyrosine kinases, induced apoptosis of proliferating endothelial cells in vitro. TG100572 inhibits downstream molecules involved in the vascular endothelial growth factor (VEGF) signaling pathway resulted in markedly diminished levels of HSV-induced angiogenesis and significantly reduced the severity of SK lesions..

Chemical Structure

TG100572 HCl
CAS# 867331-64-4 (HCl)

Theoretical Analysis

MedKoo Cat#: 406790
Name: TG100572 HCl
CAS#: 867331-64-4 (HCl)
Chemical Formula: C26H27Cl2N5O2
Exact Mass:
Molecular Weight: 512.435
Elemental Analysis: C, 60.94; H, 5.31; Cl, 13.84; N, 13.67; O, 6.24

Price and Availability

Size Price Availability Quantity
10.0mg USD 485.0 2 Weeks
50.0mg USD 1225.0 2 Weeks
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Related CAS #: 867331-64-4 (HCl)   867334-05-2 (free base)    

Synonym: TG-100572; TG 100572; TG100572; TG-100572 HCl

IUPAC/Chemical Name: 4-chloro-3-(5-methyl-3-((4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)amino)benzo[e][1,2,4]triazin-7-yl)phenol hydrochloride


InChi Code: InChI=1S/C26H26ClN5O2.ClH/c1-17-14-18(22-16-20(33)6-9-23(22)27)15-24-25(17)29-26(31-30-24)28-19-4-7-21(8-5-19)34-13-12-32-10-2-3-11-32;/h4-9,14-16,33H,2-3,10-13H2,1H3,(H,28,29,31);1H

SMILES Code: CC1=C2C(=CC(=C1)C3=C(C=CC(=C3)O)Cl)N=NC(=N2)NC4=CC=C(C=C4)OCCN5CCCC5.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 512.435 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Sharma S, Mulik S, Kumar N, Suryawanshi A, Rouse BT. An anti-inflammatory role
of VEGFR2/Src kinase inhibitor in herpes simplex virus 1-induced immunopathology.
J Virol. 2011 Jun;85(12):5995-6007. doi: 10.1128/JVI.00034-11. Epub 2011 Apr 6.
PubMed PMID: 21471229; PubMed Central PMCID: PMC3126288.

2: Doukas J, Mahesh S, Umeda N, Kachi S, Akiyama H, Yokoi K, Cao J, Chen Z,
Dellamary L, Tam B, Racanelli-Layton A, Hood J, Martin M, Noronha G, Soll R,
Campochiaro PA. Topical administration of a multi-targeted kinase inhibitor
suppresses choroidal neovascularization and retinal edema. J Cell Physiol. 2008
Jul;216(1):29-37. doi: 10.1002/jcp.21426. PubMed PMID: 18330892; PubMed Central
PMCID: PMC3032767.